ReviewTranslational psychiatry2025
The emerging role of circular RNAs in neuropsychiatric disorders.
Review in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a unique class of endogenous, single-stranded non-coding RNAs characterized by a covalently closed circular structure. They exhibit tissue-specific expression patterns and have been implicated in the pathogenesis of a wide range of diseases. In the brain, circRNAs are abundantly expressed and evolutionarily conserved, where they play critical roles in neurodevelopment, neuronal differentiation, and synaptic plasticity. Recent studies have revealed that circRNAs are broadly expressed across eukaryotic species and display distinct expression profiles associated with various pathological conditions, particularly neuropsychiatric disorders. However, despite the identification of thousands of circRNAs through high-throughput sequencing technologies, only a small subset has been functionally characterized. In this review, we underscore the emerging significance of circRNAs in neurological and psychiatric disorders. Their exceptional stability and diverse modes of action suggest that circRNAs could serve as key nodes within future precision medicine frameworks. Nevertheless, progress toward clinical translation is currently limited by incomplete mechanistic understanding, small study cohorts, and persistent challenges in therapeutic development. To overcome these barriers, more systematic, large-scale, and mechanism-driven investigations, coupled with innovative strategies and technologies, will be required to fully realize the clinical potential of circRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.