ArticleAnnals of surgical oncology2026
Sex-Associated Aspects of Referral, Resectability, and Survival in Patients with Colorectal Liver Metastases (CRLM): A Population-Based Single-Center Study of 1207 MDT-Referred Patients.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundSex-related differences in colorectal cancer biology and care are increasingly recognized, but their impact on colorectal liver metastases (CRLM) management remains unclear. Previous Swedish registry studies suggested that women undergo CRLM surgery less often than men. This study aimed to further explore sex-associated patterns of referral rates, resectability assessment, and survival in a contemporary, multidisciplinary team (MDT)-reviewed cohort of patients with CRLM.
methodsThe study enrolled all patients with CRLM referred to the Stockholm regional liver MDT between 2013 and 2021. Tumor characteristics, treatment allocation, and survival were compared by sex. Multivariable logistic and Cox regression models were used to assess predictors of resection and survival.
resultsOf 1207 MDT-referred patients, 467 (39%) were women and 740 (61%) were men. The women were younger at diagnosis and had a higher prevalence of KRAS mutations, whereas metastatic burden and extrahepatic spread were comparable between the sexes. Curative interventions were performed for 59% of the women and 62% of the men (p = 0.219), with no differences in surgical extent, complications, or postoperative outcomes. Among palliatively treated patients, survival was similar, and multivariable Cox models identified no independent association between sex and survival in any subgroup.
conclusionsIn this large, population-based MDT cohort, sex was not associated with differences in resectability, treatment, or survival. The study underscored the importance of centralized and mandatory MDT referral pathways to ensure equitable access to curative-intent treatment and standardized management for all patients with metastatic colorectal cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.