SynthesisBrain and behavior2025
Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveDepression is a global burden that causes mortality and morbidity in patients and affects millions of people worldwide. Conventional treatment of depression has limited efficacy in addressing cognitive symptoms. Probiotics, particularly psychobiotics, offer promise by modulating the gut-brain axis and improving both depressive symptoms and cognitive function. This meta-analysis provides insights into the potential of probiotics in alleviating depression-related symptoms and cognitive deficits in comparison with placebo.
methodA thorough literature search was performed using online resources such as PubMed, Embase, Cochrane, and Google Scholar. The seven randomized control trials (RCTs) met the inclusion criteria. The study was conducted in compliance with the PRISMA guidelines.
resultPatients receiving probiotics had significant alleviation of cognitive symptoms (p = 0.01; SMD, -0.90; 95% confidence interval [CI], -1.59 to -0.21; I
conclusionIn conclusion, research has demonstrated that probiotic supplementation can be a highly effective supplementary treatment for depression by effectively addressing psychological symptoms and cognitive problems. Its therapeutic potential in clinical settings should be explored by additional research to better understand its mechanisms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.