Evidence map›Paper›PMID 41319088›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Biocompatible SABRE Hyperpolarization of [1-

Patrick TomHon, Joseph Gyesi, Abubakar Abdurraheem, Stephen McBride, Anna Samoilenko, Clementinah Oladun, Erica Curran, Megan Pike, Sydney D Welch, Sydney Scofield and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  2. Hyperpolarization of [1-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Patrick TomHonIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0003-3202-9812
Joseph GyesiIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-1672-0147
Abubakar AbdurraheemIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-3916-8834
Stephen McBrideDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0001-9144-1423
Anna SamoilenkoIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Clementinah OladunIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0003-0621-5590
Erica CurranDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0009-0005-1376-5541
Megan PikeDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0002-2896-5408
Sydney D WelchIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Sydney ScofieldBiological Sciences, Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-3976-7976
Boyd M GoodsonSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois, USA.ORCID https://orcid.org/0000-0001-6079-5077
Marianna SadagurskiBiological Sciences, Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-8203-4612
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0001-6779-9978
Eduard Y ChekmenevIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-8745-8801

Funding

Research Experience & Training Coordination CoreP42ES030991 · WAYNE STATE UNIVERSITY · 2025 to 2025
$2.2M
Canagliflozin as a Neuroprotective Agent to Improve Neuroinflammation and Cognitive Function during AgingRF1AG078170 · NIA · WAYNE STATE UNIVERSITY · PI Marianna Sadagurski · 2023 to 2023
$1.2M
Benzene exposure promotes neuroinflammation and metabolic dysregulationR01ES033171 · NIEHS · WAYNE STATE UNIVERSITY · 2024 to 2025
$739k
Plug-and-play Hyperpolarized MRI of Metabolism on Clinical ScannersR01EB034197 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$594k
PIGE: The Program Integrating Genomics and the EnvironmentT32ES036169 · WAYNE STATE UNIVERSITY · 2025 to 2025
$231k
Biological and Environmental Research DE-SC0023334,DE-SC0025315National Science Foundation CHE-2404387,CHE-2404388NIA NIH HHS R01AG078170NIA NIH HHS RF1 AG078170NIBIB NIH HHS R01 EB034197NIBIB NIH HHS R01EB034197NIBIB NIH HHS R21 EB033872NIBIB NIH HHS R21EB033872NIEHS NIH HHS P30 ES020957NIEHS NIH HHS P30ES020957NIEHS NIH HHS P42 ES030991NIEHS NIH HHS P42ES030991NIEHS NIH HHS R01 ES033171NIEHS NIH HHS R01ES033171NIEHS NIH HHS T32 ES036169NIEHS NIH HHS T32ES036169
6 · The paper itself

Abstract

Ketoleucine (α-ketoisocaproate) is a novel hyperpolarized substrate for noninvasive metabolic imaging, enabling rapid, high-sensitivity detection of branched-chain amino acid flux, a pathway that is aberrant in many diseases including cancer and Alzheimer's disease. Utilizing NMR Signal Amplification by Reversible Exchange (SABRE) with an 80:20 acetone:water solvent system, we achieved >11% polarization of [1-

Indexed as

Amino Acids, Branched-ChainKeto AcidsSaccharomyces cerevisiaeCarbon IsotopesMagnetic Resonance Spectroscopyalpha-ketoisocaproic acidAmino Acids, Branched-ChainCarbon IsotopesKeto Acidsbranched‐chain amino acidcarbon‐13hyperpolarizationmetabolismNMR

Identifiers

PMID41319088
PMCPMC12743355

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.