Evidence map›Paper›PMID 41319194›Full record

ReviewClinical and translational science2025

Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital.

Sonya Tang Girdwood, Ronaldo Morales Junior, Erin Schuler, Peter Tang, Emily Diseroad, Catherine Misch, Beverly Engle, Shawn McCall, Mark E Murphy, Zachary L Taylor and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sonya Tang GirdwoodDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-7737-8499
Ronaldo Morales JuniorDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Erin SchulerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Peter TangDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Emily DiseroadDivision of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Catherine MischDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Beverly EngleDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Shawn McCallLaboratory Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Mark E MurphyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Zachary L TaylorDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-5178-2397
Tomoyuki MizunoDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Alexander A VinksDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jennifer KaplanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Funding

Antibiotic Model-Informed Precision Dosing in Critical IllnessR35GM146701 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Sonya C Tang Girdwood · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM146701NIGMS NIH HHS R35GM146701
6 · The paper itself

Abstract

There has been growing interest in precision dosing of beta-lactam antibiotics in recent years. At our institution, a quaternary children's hospital, we launched a new PK consult service utilizing a model-informed precision dosing (MIPD) approach to provide personalized dosing recommendations for cefepime. This consult service leveraged the infrastructure of an existing PK consult service at our institution for other drugs, such as immunosuppressants. In this manuscript, we describe the challenges in the development of a beta-lactam PK consult service due to fundamental differences between the new service and the existing PK consult service, such as varying levels of evidence for target goals for beta-lactam antibiotics versus immunosuppressants, and how they were addressed. We then present the workflow and infrastructure of our beta-lactam PK consult service to provide guidance for other institutions who may be interested in launching a similar service. Lessons learned throughout the process of building the service, including the importance of engaging multiple, diverse stakeholders early on and starting with one drug at a time, are provided.

Indexed as

Anti-Bacterial Agentsbeta-LactamsCefepimeHospitals, PediatricPrecision MedicineChildDrug Dosage CalculationsHumansAnti-Bacterial Agentsbeta-LactamsCefepimebeta‐lactampediatricspharmacokineticsprecision dosing

Identifiers

PMID41319194
PMCPMC12665186

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.