ArticleACS applied materials & interfaces2025
Reviving the Fight against Opioid Overdoses: Unleashing the Power of Metal-Organic Frameworks for Morphine Removal.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nanoelectronic Detection of Opioids: Machine Learning-Powered Screening With Carbon Nanotube Field-Effect Transistor Sensor Array.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of suitable medical adsorbents that exhibit a quick response at the time of an overdose is challenging. In this work, we focused on morphine (MORPH) adsorbents that efficiently abate MORPH during the acute overdose and provide, in a controlled, gradual manner, MORPH antagonist─naloxone (NAL) to effectively and safely reverse overdose and its side effects by using, as sorbent, zirconium metal-organic frameworks (MOFs). Three model MOFs, including UiO-66, UiO-67, and NU-1000, were characterized in terms of their ability to adsorb MORPH as well as NAL release in water and a simulated body fluid (SBF). Single MORPH adsorption on NU-1000 was 100% in water and 90 wt % in SBF solution. At the same time, in a single NAL release in SBF from the prepared NAL@UiO-67 composite was equal to 76%. Additionally, in the simultaneous experiment of MORPH adsorption and NAL release, a designed mixture of NU-1000/NAL@UiO-67 has shown maximum adsorption/release values in SBF solution of 89 and 8%, respectively. The in vivo and in vitro experiments confirmed the exceptional effect of prepared materials on the locomotor activity of mice and the low cytotoxicity of MOFs. In vivo fluorescent imaging has confirmed that the nano-MOFs obtained are mostly accumulated in the liver when administered intravenously.
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