Evidence map›Paper›PMID 41319265›Full record

ArticleTissue barriers2026

Placental infection by SARS-CoV-2: exploring alternative entry pathways.

Carolina Lumi Tanaka Dino, Barbara Maria Cavalli, Carolline Konzen Klein, Felipe Paes Gomes da Silva, Nicolas Henrique Borges, Ana Catharina Joaquim, Thiago Rodrigues Dos Santos, Natan de Araújo, Lucas Baena Cartens, Ana Clara Simões Flórido Almeida and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue barriers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carolina Lumi Tanaka DinoCenter for Health Sciences, Postgraduate Program of Obstetrics, Gynecology, and Women's Health, Federal University of Paraná - UFPR, Curitiba, Brazil.
Barbara Maria CavalliCenter for Health Sciences, Postgraduate Program of Obstetrics, Gynecology, and Women's Health, Federal University of Paraná - UFPR, Curitiba, Brazil.
Carolline Konzen KleinSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Felipe Paes Gomes da SilvaSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Nicolas Henrique BorgesSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Ana Catharina JoaquimCenter for Health Sciences, Federal University of Paraná - UFPR, Curitiba, Brazil.
Thiago Rodrigues Dos SantosFaculdades Pequeno Príncipe, Postgraduate Program of Biotechnology Applied to Child and Adolescent Health, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.
Natan de AraújoSchool of Medicine and Life Sciences, Postgraduate Program of Health Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Lucas Baena CartensSchool of Medicine and Life Sciences, Postgraduate Program of Health Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Ana Clara Simões Flórido AlmeidaSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Seigo NagashimaSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Caroline Busatta Vaz de PaulaSchool of Medicine and Life Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Cleber Machado-SouzaFaculdades Pequeno Príncipe, Postgraduate Program of Biotechnology Applied to Child and Adolescent Health, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.
Lucia de NoronhaSchool of Medicine and Life Sciences, Postgraduate Program of Health Sciences, Pontifical Catholic University of Paraná - PUCPR, Curitiba, Brazil.
Meri Bordignon NogueiraCenter for Health Sciences, Postgraduate Program of Obstetrics, Gynecology, and Women's Health, Federal University of Paraná - UFPR, Curitiba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The placenta possesses several structural and immunological barriers against viral infections, the SARS-CoV-2 detection in placental tissues has raised concerns regarding possible alternative viral entry mechanisms beyond the canonical ACE2/TMPRSS2-mediated pathway. In this context, the present study evaluated the immunohistochemical expression patterns of ADAM17, Cathepsin L, Clathrin, ACE-2, Furin, NRP-1, and TMPRSS2-molecules involved in SARS-CoV-2 placental entry pathways - as well as the detection of viral RNA by RT-qPCR in paraffin-embedded samples. The study included 75 paraffin-embedded placental samples (decidua and villi) collected after spontaneous placental delivery at birth from patients who tested positive for COVID-19 (COVID-19 Group), and 19 paraffin-embedded control placental samples collected prior to the COVID-19 pandemic (NON-COVID-19 Group). A statistically significant reduction in NRP-1 expression was observed in the COVID-19 group decidua (

Indexed as

COVID-19PlacentaPregnancy Complications, InfectiousSARS-CoV-2Virus InternalizationADAM17 ProteinAdultAngiotensin-Converting Enzyme 2Cathepsin LClathrinFemaleFurinHumansNeuropilin-1PregnancySerine EndopeptidasesACE2 protein, humanADAM17 ProteinADAM17 protein, humanAngiotensin-Converting Enzyme 2Cathepsin LClathrinCTSL protein, humanFurinFURIN protein, humanNeuropilin-1NRP1 protein, humanSerine EndopeptidasesTMPRSS2 protein, humanEndocytosismaternal–fetal interfaceplacentaviral entryviral infection

Identifiers

PMID41319265
PMCPMC13228962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.