ReviewJournal of advanced research2026
Macrophage-induced immunomodulation in oral tissue repair and regeneration: Recent advances and future perspectives.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Exercise attenuates cisplatin-induced anorexia-cachexia via modulation of hypothalamic inflammation and orexigenic signaling.European journal of applied physiology · 2026Article
- Chiral FeBioactive materials · 2026Article
- Immunological Microenvironment Diversity in Homogeneous and Non-Homogeneous Oral Leukoplakia.International journal of molecular sciences · 2026Article
- Tannic acid-assisted mechanical training transforms natural hydrogels into robust and bioactive membranes for guided bone regeneration.Materials today. Bio · 2026Article
- Oral Self-Care as a Preventive Strategy in Medicated Older Adults: Biological Mechanisms, Genetic Susceptibility, and Public Health Implications.Healthcare (Basel, Switzerland) · 2026Review
- Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026Article
- Harnessing the Therapeutic Potential of Extracellular Vesicles for Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Size-Optimized LDH Nanoplatelet-Reinforced GelMA Hydrogels Orchestrate Osteoimmunomodulation for Critical-Sized Bone Defect Repair.International journal of nanomedicine · 2026Article
- Immune signaling as a determinant of cellular identity and tissue function.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMaintaining immune balance plays crucial roles in the development and prognosis of injured oral tissues. Serving as critical components of immune system, macrophages are essential in accelerating oral tissue repair and regeneration. This multipart review intends to present a comprehensive overview of recent advances and future perspectives of macrophage plasticity and polarization in oral tissue repair and regeneration, thereby enhancing the understanding of macrophage-induced immunotherapeutic effects and underlying mechanisms in oral diseases.
methodsThe primary electronic databases consulted for this review included PubMed, Web of Science, and Scopus. The literature search strategy employed a comprehensive combination of keywords such as "macrophage polarization", "M1", "M2", "oral tissue repair", "periodontitis", "pulpitis", "osseointegration", "jawbone defects", and "immunotherapy". Both original research articles and authoritative review papers were selected. Furthermore, the reference lists of retrieved articles were manually examined to identify additional pertinent publications.
resultsMacrophages are derived initially from hematopoietic stem cells in the bone marrow and embryonic yolk sac progenitor cells. They encompass several polarization phenotypes, including M1, M2a, M2b, M2c, and M2d, and exert multifaceted functions by secreting soluble factors and insoluble exosomes. Encouragingly, robust immunotherapeutic potential and distinctive regulatory mechanisms of macrophages have been revealed for a variety of oral diseases, providing a breadth of perspectives and insights into the repair and regeneration of oral tissues.
conclusionsOrderly and sequential polarization of macrophages has been proposed as novel immunotherapeutic strategies and promising directions for treating oral diseases. An in-depth exploration of hidden mechanisms may contribute to structural regeneration and functional reconstruction of oral tissues.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.