Evidence map›Paper›PMID 41320180›Full record

ArticleJournal of biomedical research2026

GPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses.

Yue Wang, Qingyue Meng, Qin Zhu, Xinyi Zhang, Xinfa Wang, Junping He, Jing Cai, Xiaohong Pu, Zihe Ai, Qinya Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yue WangDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qingyue MengDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qin ZhuDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xinyi ZhangDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xinfa WangDepartment of Neurosurgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210093, China.
Junping HeDepartment of Neurosurgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210093, China.
Jing CaiDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xiaohong PuDepartment of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Zihe AiDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qinya LiDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Kedui PuDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Tingting YuDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Chen LiuDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Shen YueDepartment of Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma (MB) is the most common malignant tumor of the cerebellum in children. The Sonic Hedgehog (SHH) subgroup of MB (SHH-MB) is driven by aberrant activation of the SHH pathway; however, mutations in genes related to this pathway are relatively rare, posing challenges for therapeutic development. Glypican-6 (GPC6), a heparan sulfate proteoglycan, is highly expressed in SHH-MB. In this study, we demonstrate the synchronous expression of GPC6 with GLI family zinc finger 1 (GLI1) in both the developing cerebellum and medulloblastoma. GPC6 promotes cell proliferation, migration, and invasion in SHH-MB cell lines (DAOY and ONS-76). Consistently, GPC6 enhances the SHH pathway activity by upregulating GLI1 expression, supports ciliogenesis essential for signal transduction, and facilitates SHH ligand expression

Indexed as

extracellular vesiclesglypican-6medulloblastomaprimary ciliaSHH signaling

Identifiers

PMID41320180
PMCPMC13231367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.