Evidence map›Paper›PMID 41320692›Full record

ArticleScientific reports2025

Phosphorylation of the β

Jia-Ying Wu, Siou-Cen Li, Zeng-Weng Chen, Jyh-Perng Wang, Cheng-Yao Yang, Kuang-Po Li, Shih-Ling Hsuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia-Ying WuGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, Taichung, 402, Taiwan, ROC.
Siou-Cen LiGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, Taichung, 402, Taiwan, ROC.
Zeng-Weng ChenAnimal Technology Research Center, Agricultural Technology Research Institute, Miaoli, 350, Taiwan, ROC.
Jyh-Perng WangAnimal Technology Research Center, Agricultural Technology Research Institute, Miaoli, 350, Taiwan, ROC.
Cheng-Yao YangGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, Taichung, 402, Taiwan, ROC.
Kuang-Po LiGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, Taichung, 402, Taiwan, ROC.
Shih-Ling HsuanGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, Taichung, 402, Taiwan, ROC. hsuan@nchu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, produces various virulence factors, including the exotoxin ApxI, which contributes to disease pathogenesis. ApxI induces cytotoxicity through porcine lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) while concurrently attenuating Akt activity. This study aimed to investigate the regulatory role of porcine CD18, focusing on the tyrosine 735 residue in its cytoplasmic tail, and to examine the involvement of Akt in ApxI-induced cytotoxicity. Through transfection experiments, we demonstrated that the expression of porcine CD18 alone in ApxI-insensitive human embryonic kidney 293 cells conferred susceptibility to ApxI, while cotransfection of porcine CD11a with porcine CD18 resulted in the highest ApxI sensitivity, accompanied by reduced Akt activity. Substituting the wild-type CD18 with a CD18 harboring a tyrosine 735-to-proline (CD18

Indexed as

Actinobacillus InfectionsActinobacillus pleuropneumoniaeBacterial ProteinsCD18 AntigensHemolysin ProteinsProto-Oncogene Proteins c-aktAnimalsDown-RegulationHEK293 CellsHumansPhosphorylationSwineSwine DiseasesApxI toxin, BacteriaBacterial ProteinsCD18 AntigensHemolysin ProteinsProto-Oncogene Proteins c-aktActinobacillus pleuropneumoniaeAktApxILFA-1

Identifiers

PMID41320692
PMCPMC12783832

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.