Evidence map›Paper›PMID 41320779›Full record

Observational studyBJOG : an international journal of obstetrics and gynaecology2026

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Bita Tristani-Firouzi, Lisa Pappas, Merry Joseph, Maryam Zeinomar, Michelle P Debbink, Joseph Mims, Rafael Guerrero, Barry Moore, Robert M Silver, Tsegaselassie Workalemahu and 4 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bita Tristani-FirouziDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-3978-9139
Lisa PappasDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Merry JosephDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Maryam ZeinomarDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Michelle P DebbinkDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Joseph MimsDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Rafael GuerreroDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Barry MooreDepartment of Human Genetics, University of Utah, Salt Lake City, Utah, USA.
Robert M SilverDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Tsegaselassie WorkalemahuDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-4571-9740
David HaasDepartment of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana, USA.
Jonathan G StellerDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of California, Irvine, Orange, California, USA.
George SaadeDepartment of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Nathan R BlueDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-2187-3428

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
Prevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063053 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2010 to 2014
$1.7M
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk U10HD063020 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063046 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WING, DEBORAH A · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063041 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2010 to 2014
$1.5M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063048 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI PARRY, SAMUEL I. · 2010 to 2014
$1.5M
Dissecting the Genetic Etiology of Preterm Birth in Nulliparous WomenU10HD063037 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$1.2M
Adverse Outcomes in Nulliparous Pregnancies: The Ohio CollaborativeU10HD063072 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI MERCER, BRIAN M. · 2010 to 2014
$1.2M
Individualization of Fetal Growth Assessment using Maternal Genetics and Explainable AIK08HD113835 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Nathan Richard Blue · 2024 to 2026
$473k
Indiana University Grand Challenges Precision Health InitiativeNational Institute of Child Health and Human DevelopmentNCATS NIH HHS UL1 TR002538NCRR NIH HHS UL1 RR025764NICHD NIH HHS K08 HD113835NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063036NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072NIH HHSUniversity of Utah Data Science Hub
6 · The paper itself

Abstract

objectiveMaternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight (GRS COHORT:

designSecondary analysis of a prospective observational cohort of nulliparous patients.

settingEight U.S. recruitment centers. POPULATION OR SAMPLE: Participants in the parent study with available maternal DNA.

methodsWe used log-linear modelling to test the association of maternal GRS

main outcome measuresBirth weight.

resultsAmong 8147 eligible participants, GRS

conclusionsThis GRS

Indexed as

Birth WeightRacial GroupsAdultFemaleGenetic Risk ScoreGenotypeHumansInfant, NewbornPregnancyProspective StudiesRisk FactorsUnited StatesWhiteWhite Peopleequityfoetal growthgenetic risk scorepolygenic risk score

Identifiers

PMID41320779
PMCPMC12884248

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.