ReviewMetabolism open2025
Update on the impact of lipid and glucose control on diabetic wound healing.
Review in Metabolism open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development of a core descriptor set for studies assessing interventions for diabetes-related foot ulceration.Diabetologia · 2026Pooled it
- Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications.Bioactive materials · 2027Review
- [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Comprehensive Review of Hydrogel-Mediated Strategies for Diabetic Wound Healing.International journal of molecular sciences · 2026Review
- Multidimensional Regulatory Mechanisms and Targeted Therapeutic Strategies for Inhibited Keratinocyte Proliferation in Diabetic Wounds.Drug design, development and therapy · 2026Review
- Hyperglycemia Modulates the Expression of MAPK13, TSP1, and CXCR2 During Wound Healing in Sprague Dawley Rats.Biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes current insights into the molecular mechanisms by which hyperglycemia and dyslipidemia contribute to chronic diabetic wounds. It discusses the roles of key metabolic pathways, including the hexosamine biosynthetic and polyol pathways, along with the significance of inflammatory mediators and oxidative stress in this process. In addition, emerging therapeutic strategies are evaluated, such as the use of metformin to activate AMPK, PPAR agonists, SGLT2 inhibitors, and GLP-1 receptor agonists, which hold promise for modulating the inflammatory microenvironment and restoring cellular function. Combination therapies, advanced wound dressings, negative pressure wound therapy (NPWT), hyperbaric oxygen therapy (HBOT), and regenerative approaches such as stem cell therapies and bioengineered skin substitutes are also reviewed as integrated strategies that target both systemic metabolic dysregulation and local wound-specific challenges. These findings underscore the critical role of improved glucose and lipid control in optimizing diabetic wound healing and suggest that personalized, multimodal therapeutic approaches may offer enhanced clinical outcomes for patients with diabetic ulcers and other chronic wounds.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.