Evidence map›Paper›PMID 41321489›Full record

ArticleFrontiers in physiology2025

Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.

Helena Hernández-Cuervo, Ramani Soundararajan, Sahebgowda Sidramagowda Patil, Mason T Breitzig, Matthew Alleyn, Venkata Ramireddy Narala, Richard Lockey, Lakshmi Galam, Narasaiah Kolliputi

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Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Helena Hernández-CuervoDepartment of Dermatology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Ramani SoundararajanDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Sahebgowda Sidramagowda PatilAnatomy and Cell Biology Department, University of Iowa, Iowa City, IA, United States.
Mason T BreitzigDivision of Epidemiology, Department of Public Health Sciences, Penn State College of Medicine, Pennsylvania State University, Hershey, PA, United States.
Matthew AlleynDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Venkata Ramireddy NaralaDepartment of Zoology, Yogi Vemana University, Kadapa, India.
Richard LockeyDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Lakshmi GalamDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Narasaiah KolliputiDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Administering high levels of oxygen is a life-sustaining measure in critically ill lung subjects. However, prolonged hyperoxia exposure increases reactive oxygen species (ROS) that exacerbate oxidative stress, mitochondrial dysfunction, respiratory failure, and cell death. Mitochondria play a critical role in hyperoxia-induced acute lung injury (HALI). The specific role of the Polycomb Repressive Complex 1 protein BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) in mitochondrial damage remains unknown. Methods: Results: Mice lacking Discussion:

Indexed as

ARDS (acute respiratory disease syndrome)BMI1halihyperoxia-induced acute lung injurymitochondria

Identifiers

PMID41321489
PMCPMC12658778

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.