Evidence map›Paper›PMID 41321540›Full record

ArticleGlomerular diseases

Epidemiology of Pediatric Nephrotic Syndrome: Real-World Data from Brazil.

Paulo Cesar Koch-Nogueira, Luciana de Santis Feltran, Maria Fernanda Carvalho de Camargo, Débora Villar Martins, João Bosco Pesquero, Patricia Varela, Andreia Watanabe, Mara Sanches Guaragna, Vera Maria Santoro Belangero, Luiz Fernando Onuchic

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Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paulo Cesar Koch-NogueiraDivision of Pediatric Nephrology, São Paulo Federal University - UNIFESP, São Paulo, Brazil.
Luciana de Santis FeltranDivision of Pediatric Kidney Transplantation, São Paulo Samaritan Hospital, São Paulo, Brazil.
Maria Fernanda Carvalho de CamargoDivision of Pediatric Kidney Transplantation, São Paulo Samaritan Hospital, São Paulo, Brazil.
Débora Villar MartinsDivision of Pediatric Nephrology, São Paulo Federal University - UNIFESP, São Paulo, Brazil.
João Bosco PesqueroCenter for Research and Molecular Diagnostic of Genetic Diseases - Department of Biophysics, São Paulo Federal University, São Paulo, Brazil.
Patricia VarelaCenter for Research and Molecular Diagnostic of Genetic Diseases - Department of Biophysics, São Paulo Federal University, São Paulo, Brazil.
Andreia WatanabeDepartment of Pediatrics, University of São Paulo School of Medicine, São Paulo, Brazil.
Mara Sanches GuaragnaDepartment of Medical Genetics and Genomic Medicine, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
Vera Maria Santoro BelangeroDepartment of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
Luiz Fernando OnuchicDivision of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The present study aimed to describe the clinical and demographic characteristics of nephrotic syndrome in children from a large, highly genetically admixed Latin American country and to identify key challenges in managing pediatric nephrotic syndrome in Brazil. Methods: This observational, multicenter study included a patient sample from 21 pediatric nephrology centers. Descriptive statistics were employed to analyze the outcomes. Results: Data were collected from 597 patients; 333 (56%) were male, with a median age of 3.5 years (interquartile range [IQR], 2.2-6.0) at disease onset. There was no consensus among centers regarding initial treatment duration, criteria of response to treatment, although all patients received corticosteroids. After a median follow-up of 4.3 years (IQR, 2.0-7.4), 423 (71.0%) patients were classified as steroid-sensitive, and 172 (28.9%) as steroid-resistant. Progressive kidney dysfunction (chronic kidney disease [CKD] stages 4/5) was observed in 35 (5.9%) patients. Despite 224 patients undergoing kidney biopsy and 172 being classified as steroid-resistant, only 8 (1.3%) children underwent genetic testing. Electron microscopy was performed in only 19 kidney biopsies. Conclusion: Despite the inherent limitations of observational studies, this investigation presents valuable clinical and demographic data on nephrotic syndrome from a previously underrepresented region. It highlights significant unmet medical needs in Brazil, including the need for consensus on treatment protocols and standardized definitions of responses to treatment. In addition, the near absence of genetic testing in steroid-resistant nephrotic syndrome represents a critical gap that requires prompt intervention.

Indexed as

Kidney functionNephrotic syndromeObservational studyPediatric nephrology

Identifiers

PMID41321540
PMCPMC12659168

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.