Evidence map›Paper›PMID 41321620›Full record

ArticleiScience2025

Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing

Isabella Leite Coscarella, Olalekan H Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N Brown, Diego A R Zorio, Brian K Washburn, Cynthia Vied, Bjorn C Knollmann and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Article
  3. Why the septum thickens in hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Isabella Leite CoscarellaBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Olalekan H UsmanBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Lili WangDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Maicon Landim-VieiraBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Lillian WirstiukBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Amber N BrownBiological Science, Florida State University, Tallahassee, FL, USA.
Diego A R ZorioBiological Science, Florida State University, Tallahassee, FL, USA.
Brian K WashburnBiological Science, Florida State University, Tallahassee, FL, USA.
Cynthia ViedTranslational Science Laboratory, Florida State University, Tallahassee, FL, USA.
Bjorn C KnollmannDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher SolísHealth, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Vitold E GalkinDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
P Bryant ChaseBiological Science, Florida State University, Tallahassee, FL, USA.
J Travis HinsonThe Jackson Laboratory, Farmington, CT, USA.
Jerome IriantoBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Jose Renato PintoBiomedical Sciences, Florida State University, Tallahassee, FL, USA.

Funding

Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
NHLBI NIH HHS R35 HL144980
6 · The paper itself

Abstract

Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing

Indexed as

Biological sciencesCell biologyNatural sciencesStem cells research

Identifiers

PMID41321620
PMCPMC12663735

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.