ArticleiScience2025
Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During tumorigenesis, fibroblasts transition from homeostatic cells to cancer-promoting entities, a process potentially mediated by long non-coding RNAs (lncRNAs). While some oncogenic lncRNAs facilitate carcinogenesis, the role of downregulated homeostatic lncRNAs remains unclear. This study reveals that LINC01133, primarily expressed in fibroblasts, is significantly reduced in cancer-associated fibroblasts. The decreased expression of LINC01133 in gastric adenocarcinoma-associated fibroblasts diminishes its extracellular-vesicle-mediated uptake by tumor cells, leading to the acceleration of gastric cancer progression. KLF4 regulates the transcription of LINC01133 in fibroblasts. Mechanistically, binding of LINC01133 to the 173-191 residue region of CDC42 suppresses the activity of its downstream kinases PAK3 and MLK3, and LINC01133 was also the sponge of miR-199a-5p, thereby competing with PHLPP1.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.