ArticleMaterials today. Bio2025
Anti-lung cancer therapy using nano-assembly particles of traditional Chinese Medicine formula.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Self-assembled nanoparticles from natural herbs alleviate osteoarthritis by targeting retinol metabolism and inhibiting chondrocyte ferroptosis.Materials today. Bio · 2026Article
- Carrier-free self-assembled nanomedicines from natural small molecules: advances and perspectives for disease treatment.RSC advances · 2026Review
- A novel nanotherapeutic strategy: rescuing nucleus pulposus cells from fatty acid metabolic disorder and pyroptosis through ACOT13 by Chinese herbal formula nanoparticles.Journal of nanobiotechnology · 2026Article
- TCM-Driven Circadian Modulation in Cancer: Engineering Spatiotemporal Drug Delivery for Precision Oncology.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nano-assembly particles (NAPs) isolated from Traditional Chinese Medicine (TCM) formulations retain a better multi-component overall effect than isolated single active ingredient, which gradually emerging as a transformative approach for the pharmacodynamic and pharmacological research of TCM. This study introduced an innovative research paradigm for investigating the mechanisms of TCM formulas and proposes the groundbreaking concept of "TCM nano-formulated prescriptions" using Yi-Fei-San-Jie Formula (YFSJF) as a clinically study model. Firstly, based on the favorable outcomes in 31 clinical patients with pulmonary space-occupying lesions who received YFSJF treatment, the anti-tumor efficacy of NAPs isolated from the YFSJF decoction was systematically evaluated. Furthermore, the basic material components and underlying mechanism of NAPs were elucidated. Finally, 248 artificially synthetic nanoparticles developed by central bioactive components of YFSJF were used to study the self-assembly process, anti-tumor activity and safety profile. This study firstly demonstrated the potential NAPs-based replacement of traditional formulas and establishes a pioneering methodology for screening multi-component NAPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.