Evidence map›Paper›PMID 41322151›Full record

ReviewMaterials today. Bio2025

Application of injectable hydrogels in the central and peripheral nervous system as a unique and flexible platform for neural tissue repair.

Kun Wu, Zhihe Yun, Wu Xue, Tao Yu, Anyuan Dai, Inbo Han, Vit Kotheeranurak, Worawat Limthongkul, Yanting Liu, Qinyi Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kun WuDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Zhihe YunDepartment of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China.
Wu XueDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Tao YuDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Anyuan DaiDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Inbo HanDepartment of Neurosurgery, CHA University School of Medicine, CHA Bundang Medical Center, China.
Vit KotheeranurakDepartment of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Worawat LimthongkulDepartment of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Yanting LiuDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Qinyi LiuDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nervous system, comprising the central and peripheral components, is essential for regulating physiological functions. Damage to neural tissue often results in severe motor and sensory deficits, with limited endogenous regenerative capacity posing major challenges for repair. Tissue engineering offers promising strategies for neural regeneration by integrating cells, biomaterial scaffolds, and drug delivery systems. Among biomaterials, injectable hydrogels have attracted significant attention due to their biocompatibility, biodegradability, flexibility, and ability to undergo minimally invasive in situ gelation. These hydrogels serve as versatile carriers for cells and therapeutic agents, enabling precise delivery to hard-to-reach tissues while promoting neural repair. This review highlights recent advances in the design, preparation, and application of injectable hydrogels for neural tissue engineering. We discuss their roles in regenerating the brain, spinal cord, and peripheral nerves, address current challenges, and provide perspectives on future developments. Collectively, injectable hydrogels represent a promising platform for developing next-generation regenerative therapies aimed at restoring both anatomical structure and functional outcomes in neural tissues.

Indexed as

Central nervous systeminjectable hydrogelsNeural tissue engineeringPeripheral nervous systemRegenerative medicine

Identifiers

PMID41322151
PMCPMC12663675

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.