Evidence map›Paper›PMID 41322153›Full record

ReviewMaterials today. Bio2025

Engineering neural recovery: Micro/nano-structured materials for nerve regeneration.

Hui Zhang, Junhui Sha, Sixing Cao, Jin Feng, Xinyi Pang, Dongyu Xu, Yangnan Hu, Minli Li, Chen Zhang, Yu Wang and 2 more

Abstract readReview
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui ZhangState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Junhui ShaState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Sixing CaoState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Jin FengDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Xinyi PangCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, China.
Dongyu XuState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Yangnan HuState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Minli LiDepartment of Rheumatology and Immunology, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 2100096, China.
Chen ZhangBeijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China.
Yu WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
Huan WangThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.
Renjie ChaiState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micro- and nano-structures play a crucial role in modulating nerve cell behavior and influencing the distribution of endogenous factors or exogenous therapeutic agents, which significantly affect the outcome of nerve tissue regeneration. Herein, the development of micro/nano-structured materials for neural tissue regeneration is reviewed. Also, the main manufacturing strategies of micro- and nano-structures are introduced, including electrospinning, 3D printing, microfluidics, and freezing casting. Particularly, multiple micro/nano-structured materials and their applications in both peripheral nerve and spinal cord injury repair are highlighted. Furthermore, the challenges and prospects of micro/nano-structured materials for nerve regeneration are presented and discussed. Finally, the challenges and outlook for developing the next-generation structured materials are summarized. This review provides helpful knowledge and inspires researchers with more promising ideas.

Indexed as

Micro/nano-structured materialsNerve scaffoldPeripheral nerve repairSpinal cord repairTissue engineering

Identifiers

PMID41322153
PMCPMC12661459

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.