Evidence mapPaperPMID 41322244Full record

Trial reportOpen forum infectious diseases2025

Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy.

Todd Hulgan, Kristine M Erlandson, Yuki Bradford, Katherine Tassiopoulos, Kunling Wu, Sara H Bares, Todd T Brown, Jordan E Lake, Michael Leonard, Grace A McComsey and 4 more

Abstract readClinical Trial
In one paragraph

Trial report in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Todd HulganVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-3339-067X
Kristine M ErlandsonUniversity of Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0003-0808-6729
Yuki BradfordUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katherine TassiopoulosHarvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Kunling WuHarvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Sara H BaresUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-2130-2505
Todd T BrownJohns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-8599-278X
Jordan E LakeUTHealth Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-0640-5514
Michael LeonardVanderbilt University Medical Center, Nashville, Tennessee, USA.
Grace A McComseyCase Western Reserve University, Cleveland, Ohio, USA.
Marylyn D RitchieUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1208-1720
Paul E SaxBrigham and Women's Hospital, Boston, Massachusetts, USA.
John R KoetheVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-6490-6942
David W HaasVanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
Pharmacogenomics of HIV TherapyR01AI077505 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$807k
NIAID NIH HHS R01 AI077505NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Given the melanocortin-4 receptor's (MC4R) importance in obesity, we examined associations between

Indexed as

body weight changesHIVhuman geneticsintegrase inhibitorsmelanocortin-4 receptor

Identifiers

PMID41322244
PMCPMC12662048

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.