ArticleMarine life science & technology2025
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways.
Article in Marine life science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glucocorticoids, crucial regulatory hormones involved in the stress response, significantly influence growth, development, and metabolism through activation of the glucocorticoid receptor (GR). Hypoxia-inducible factor 3 alpha (HIF-3α), the least characterized paralog among three HIF-α proteins, plays a role in adaptation to oxygen level changes and metabolic reprogramming. Despite the potential functional overlaps between GR and HIF-3α pathways in regulating metabolism, their crosstalk remains poorly understood. Here, we demonstrate a regulatory mechanism governing the crosstalk between these two transcription factor pathways. We found that upon ligand activation, GR binds to the intronic region of the Supplementary Information: The online version contains supplementary material available at 10.1007/s42995-025-00306-9.
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