ReviewBioImpacts : BI2025
Genetic engineering frontiers in cell manipulation-based tissue engineering: A comprehensive review.
Review in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Regenerative Therapy at the Crossroads: From Cell-Based to Cell-Free Precision Medicine.Bioengineering (Basel, Switzerland) · 2026Article
- Advances in enhanced mesenchymal stem cell technologies: innovations and therapeutic applications.Frontiers in cell and developmental biology · 2026Review
- Biomimetic Scaffolds and Extracellular Matrix-Based Strategies for Myofiber Regeneration in Volumetric Muscle Loss.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: A new era of regenerative medicine has been ushered in by the combination of tissue engineering and genetic engineering, offering unprecedented opportunities to address the growing demand for functional tissue replacements. This narrative review explores cutting-edge approaches in cell manipulation-based tissue engineering through the lens of genetic engineering, highlighting the transformative potential of this synergy. Methods: We critically examine the application of advanced genetic engineering techniques, including CRISPR-Cas9, TALENs, and synthetic biology, in modifying cellular behaviors and functions for tissue engineering. The review encompasses a diverse range of engineered tissues, from cartilage and bone to cardiac, neural, skin, and vascular constructs, elucidating how genetic manipulation enhances their functionality and physiological relevance. We further investigate the integration of these genetic approaches with emerging technologies such as 3D-bioprinting, microfluidics, and smart biomaterials, which collectively expand the horizons of complex tissue fabrication. Results: The review delves into pioneering trends, including in vivo genetic engineering for tissue regeneration and the development of patient-specific engineered tissues, discussing their implications for personalized medicine. We address the field's challenges, including long-term genetic stability, scalability, and off-target effects, while also considering the ethical implications and evolving regulatory landscape of genetically engineered tissues. Emerging technologies in genetic engineering, including base editing and synthetic genetic circuits, have been explored for their potential to create "smart" tissues capable of dynamic environmental responses. The review also highlights the synergistic potential of combining genetic engineering with stem cell technologies to enhance tissue functionality and immunological compatibility. Conclusion: This comprehensive review concludes by underscoring the transformative impact of genetic engineering on cell manipulation-based tissue engineering. While significant challenges persist, the rapid advancements in this field herald a future where genetically tailored, functional tissue constructs could revolutionize regenerative medicine, offering new hope for addressing critical unmet medical needs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.