ArticleBioImpacts : BI2025
Autophagy stimulation influenced the angiogenesis and metastasis behavior of human triple-negative breast cancer cells.
Article in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Multifaceted Role of Extracellular Vesicles in Triple Negative Breast Cancer.International journal of molecular sciences · 2026Review
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12 authors.
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Abstract
Introduction: Breast cancer (BC) is a devastating condition with high morbidity and mortality rates in females. Autophagy is an early-stage cell response against stressful conditions. Emerging data have revealed the autophagy-angiogenesis interaction in terms of tumor development and metastasis. Methods: Here, the angiogenesis behavior of human MDA-MB-231 cells was monitored after modulation of autophagy response in the presence of free 3-methyladenine (3-MA), metformin (Met), or drug-loaded exosomes (3-MA@Exos and Met@Exos). Orthotopic transplantation was done using human BC cell-laden alginate/gelatin (Alg/Gel) microspheres in mice after treatment with Met and/or 3-MA. Results: Met, and/or Met@Exos increased the cell migration rate and promoted human endothelial cell migration compared to the control cells ( Conclusion: These data indicate that autophagy modulation can alter the angiogenesis and metastatic behavior of human BC cells
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