ArticleACS omega2025
Flavivirus Nonstructural Protein 1‑Driven Coagulation via Tissue Factor-Bearing Microvesicles: A Pilot Study.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Microparticles Released by Dengue Virus-Infected Monocytes Mediate Endothelial Activation and Vasculopathy.International journal of molecular sciences · 2026Article
- Coagulopathy in viral haemorrhagic fevers and beyond: molecular mechanisms and targeted interventions.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flaviviruses, such as dengue and West Nile, cause diverse clinical symptoms and trigger varied clinical outcomes, partly driven by the secreted nonstructural sNS1 protein (sNS1). This study examined how sNS1 from neurotropic and hemorrhagic flaviviruses affects coagulation and inflammation using human monocytic (THP-1) cells. sNS1 from neurotropic viruses (e.g., West Nile, Japanese encephalitis) increased tissue factor (TF) expression and the release of TF-bearing microvesicles, promoting procoagulant activity. In contrast, sNS1 from hemorrhagic viruses (e.g., dengue) showed anticoagulant effects. These divergent responses correlated with the virus-specific modulation of interleukin-6 (IL-6), suggesting that inflammation plays a central role in sNS1-mediated vascular changes. The findings identify sNS1 as a key virulence factor influencing flavivirus pathogenesis through hemostatic and immune pathways, offering a potential target for therapeutic intervention.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.