ArticleCureus2025
Incidence of Subclinical Hypothyroidism in Obese Adults and Its Metabolic Implications: A Prospective Cohort Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundSubclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) and normal free thyroxine (FT4) levels. It may also assume the status of comorbidity with obesity and may cause augmented dyslipidemia, insulin resistance, and cardiovascular disease. The aim of the current study was to estimate the prevalence of SCH and its association with the metabolic aberrations in obese adults.
methodsIn this prospective cohort study, the random sampling method was used to recruit 200 obese adults (body mass index (BMI) 30 kg/m
resultsSCH was present in 41.0% (82/200) of obese adults. SCH patients had significantly greater BMI, fasting glucose, HOMA-IR, total cholesterol, and LDL-C (all p < 0.05) but lower levels of HDL-C (p = 0.004). TSH showed positive correlations with BMI (r = 0.32), HOMA-IR (r = 0.41), and lipid abnormalities and a negative correlation with HDL-C (r = -0.22, p = 0.046).
conclusionSCH was seen to be more common in obese adults and was strongly associated with poor metabolic phenotypes. Thyroid screening within the early years of obese patients would facilitate an appropriate early diagnosis and treatment process to mitigate cardiometabolic risk.
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