ArticleCureus2025
Atypical Teratoid/Rhabdoid Tumor of the Sellar Region in an Elderly Patient: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical teratoid/rhabdoid tumor (ATRT) is a rare and highly malignant central nervous system (CNS) neoplasm, most commonly diagnosed in children and only infrequently reported in older adults. Classified as a World Health Organization (WHO) grade IV tumor, ATRT carries a poor prognosis and typically requires aggressive, multimodal treatment. Management in elderly patients is particularly challenging due to comorbidities, a lack of evidence-based guidelines, and heightened risk of treatment-related toxicity. We report the case of a 75-year-old woman with hypertension and hyperlipidemia who presented with progressive dizziness, headache, and blurry vision. Imaging revealed a pituitary macroadenoma compressing the optic chiasm. Following transsphenoidal hypophysectomy, histopathology unexpectedly confirmed ATRT, CNS WHO grade IV. The patient initiated craniospinal radiation and systemic chemotherapy; however, her course was complicated by severe thrombocytopenia, critical illness myopathy, and persistent encephalopathy attributed to prolonged steroid use and metabolic derangements. Interval imaging demonstrated stable disease with reduced mass effect on the optic chiasm. Due to poor treatment tolerance, radiation therapy was discontinued after 26 sessions, and she was discharged to rehabilitation with plans for continued chemotherapy. Unfortunately, her condition further deteriorated due to treatment-related complications, and she ultimately passed away under hospice care. This case underscores the diagnostic and therapeutic challenges of ATRT in older adults, a population for whom standard pediatric-based regimens may be excessively toxic. It highlights the need for individualized, patient-centered treatment strategies that prioritize disease control, treatment tolerance, functional status, and quality of life.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.