ArticleFood & nutrition research2025
Fructose-containing sugars and metabolic risk: a systematic review and meta-analysis.
Article in Food & nutrition research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The oral und systemic health risks of sugar consumption: an umbrella review.Clinical oral investigations · 2026Pooled it
- Daily Use of Caloric and Artificial Sweeteners Among Hungarian Adults with Diabetes: Socioeconomic and Dietary Associations.Nutrients · 2026Article
- Leveraging dynamic serum uric acid trajectories for risk stratification in hospitalized HFpEF patients.Frontiers in nutrition · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fructose-containing sugars are widely consumed, yet their metabolic effects remain debated. Objective: This meta-analysis aimed to evaluate the impact of different fructose-containing sugars on glycaemic control, lipid profiles, and uric acid levels in adults. Methods: A total of 17 study codes from seven clinical trials were included, with intervention durations ranging from 7 h to 49 days. Interventions were classified as fructose, fructose-glucose mixtures (F/G), honey, or sucrose. Comparators varied and included unsweetened beverages, artificial sweeteners, and habitual diets. Meta-analyses using random-effects models assessed outcomes including fasting blood glucose (FBG), serum insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL-c), and uric acid. Effect sizes were reported as Hedges' Results: Fructose-glucose mixtures intake significantly increased FBG (Hedges' Conclusion: The short-term consumption of added sugars - fructose, sucrose, and F/G mixtures - had minimal effects on FBG, insulin, triglycerides (TG), non-esterified fatty acids (NEFAs), high-density lipoprotein cholesterol (HDL-c), and VLDL-c. However, significant increases in TC and LDL-c were observed, particularly with fructose and sucrose, indicating adverse effects on lipid metabolism. Some fructose interventions, especially those using high-fructose corn syrup, also showed marked increases in uric acid. While acute metabolic changes were limited, these findings suggest that regular intake of added sugars may elevate cardiometabolic risk. Long-term studies are warranted to clarify chronic effects and inform dietary guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.