ArticleBioactive materials2026
Stromal vascular fraction self-assembles vascularized osteogenic organoids with immunomodulatory functions.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- [Preservation of necrotic bone structures: an alternative to osteonecrosis of femoral head replacement therapy].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Analysis of the efficacy of autologous adipose-derived stromal vascular fraction and calcium phosphate bone cement combined with core decompression in patients with femoral head necrosis: a retrospective study.BMC musculoskeletal disorders · 2026Article
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17 authors.
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Abstract
Bone tissue engineering has enormous potential for treating complex orthopedic conditions such as Large Bone Defects (LBDs), delayed union or non-union fractures, and Osteonecrosis (ON). On the other hand, the adipose tissue-derived Stromal Vascular Fraction (SVF) comprises a heterogeneous population of cells, including Adipose-Derived Mesenchymal Stem Cells (ADSCs), Endothelial Progenitor Cells (EPCs), pericytes, and Hematopoietic Stem Cells (HSCs). Owing to its ease of acquisition, abundance, and the intrinsic involvement of its cellular components in bone repair, the SVF is presently considered a viable source for constructing osteogenic organoids. Herein, we leveraged the self-assembly capacity of SVF cells to construct spatially complex organoids with osteogenic, angiogenic, and immunomodulatory properties that mimic native tissues. Compared to spheroids from ADSCs alone, SVF cells exhibited natural tissue-like spatial organization, as well as superior osteogenic, angiogenic, and immunomodulatory potential, after two weeks of 3D spheroid culture. Furthermore, SVF-derived organoids showed distinct spatial architectures and functional profiles under both the growth and osteogenic induction conditions. Proteomic analysis and cytokine array profiling further revealed that SVF organoids were functionally enriched in the cytokine signaling and inflammatory/immune regulation pathways, with greater Extracellular Matrix (ECM) production observed under growth conditions compared to osteogenic induction. Moreover,
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