Evidence map›Paper›PMID 41323204›Full record

ArticleBioactive materials2026

High drug-loaded supramolecular microgels enabled by controlled in-droplet self-assembly for adaptive treatment of inflammatory arthritis.

Zhenyang Wei, Mingyu Zhu, Shuxian Wang, Jouni Hirvonen, Xiangliang Yang, Hélder A Santos, Yaping Ding, Wei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenyang WeiNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Mingyu ZhuNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Shuxian WangNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Jouni HirvonenDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, 00014, Finland.
Xiangliang YangNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Hélder A SantosDepartment of Biomaterials and Biomedical Technology, University Medical Center Groningen (UMCG), The Personalized Medicine Research Institute (PRECISION), University of Groningen, Ant. Deusinglaan 1, Groningen, 9713, AV, the Netherlands.
Yaping DingNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Wei LiNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supramolecular hydrogels derived from low-molecular-weight gelators (LMWGs) have attracted considerable interest in drug delivery due to their exceptional biocompatibility and responsiveness to physiological microenvironments. However, fabricating microgel formulations based on LMWGs is extremely challenging due to the intrinsic fragility of the self-assembled networks. To mitigate the thermodynamic limitation of LMWGs, we developed an in-droplet self-assembly strategy to fabricate spherical supramolecular microgels. In this approach, mild droplet solidification ensures that ascorbyl palmitate (AP) molecules self-assemble into nanosheets through hydrophobic interactions and hydrogen bonding. As the droplets shrink, these nanosheets concentrate, interpenetrate with each other and form stable microgels. The palmitate-based prodrugs were successfully incorporated into the interdigitated bilayer structure, achieving high drug-loading degree (36.4-47.2 wt%).

Indexed as

Adaptive treatmentDroplet microfluidicsInflammatory arthritisSelf-assemblySupramolecular microgels

Identifiers

PMID41323204
PMCPMC12661458

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.