Evidence map›Paper›PMID 41323334›Full record

ReviewAPL bioengineering2025

Rules of life at the interface of calcium signaling and mechanobiology.

Linlin Li, David Gazzo, Shams Mowafak Saad, Nissa J Larson, Eugene S Kim, Nilay Kumar, Mayesha Sahir Mim, Mothishwar Jayaraman Krishnan, Benjamin Speybroeck, Chang Ding and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Linlin LiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-9667-2965
David GazzoORCID https://orcid.org/0000-0002-9925-1744
Shams Mowafak SaadDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-4618-9027
Nissa J LarsonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-0466-3966
Eugene S KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0009-0001-3782-624X
Nilay KumarWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0009-0007-7164-1656
Mayesha Sahir MimORCID https://orcid.org/0000-0002-8488-6181
Mothishwar Jayaraman KrishnanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0009-0009-4051-6267
Benjamin SpeybroeckBioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana 46556, USA.ORCID https://orcid.org/0009-0002-4519-6353
Chang DingDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0009-0001-3886-9575
Shulan XiaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0003-4224-4196
Mary C MullinsDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID https://orcid.org/0000-0002-9979-1564
Anjali S Iyer-PascuzziDepartment of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0001-5356-4350
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-9254-9951
Elsje PienaarWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-5408-8795
Janice P EvansDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0002-1933-8971
David M UmulisWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0003-1913-2284
Jeremiah J ZartmanORCID https://orcid.org/0000-0001-7195-7203

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Living systems process a broad range of internal and external stimuli, respond to environmental constraints, and adapt to various conditions through tight coordination between signaling networks and cellular mechanics. Among these, calcium signaling and cytoskeletal regulation form an essential interplay that spans multiple scales of biological organization-from ion-protein interactions to intercellular communication and tissue-level behaviors. Calcium ions (Ca

Identifiers

PMID41323334
PMCPMC12659936

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.