Evidence map›Paper›PMID 41323439›Full record

ArticlemicroPublication biology2025

Loss of uterine EGR2 contributes to age-associated decline in fertility in female mice.

Sudikshya Paudel, Magdalina J Cummings, Steven L Young, Xiaoqiu Wang

Abstract read
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sudikshya PaudelDepartment of Animal Science, North Carolina State University, Raleigh, North Carolina, United States.
Magdalina J CummingsDepartment of Animal Science, North Carolina State University, Raleigh, North Carolina, United States.
Steven L YoungReproductive Endocrinology and Infertility, Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States.
Xiaoqiu WangDepartment of Animal Science, North Carolina State University, Raleigh, North Carolina, United States.

Funding

Deciphering molecular mechanisms controlling age-associated uterine adaptabilityto pregnancyR01HD111463 · NICHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaoqiu Wang · 2023 to 2026
$2.5M
TET2 as a novel epigenetic regulator for uterine function and fertilityR03HD112581 · NICHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI WANG, XIAOQIU · 2023 to 2023
$152k
NICHD NIH HHS R01 HD111463NICHD NIH HHS R03 HD112581
6 · The paper itself

Abstract

Early growth response 2 (Egr2) is a pleiotropic zinc finger transcription factor with established roles in neural and immune system, but its uterine function remains poorly understood. We found that uterine EGR2 is expressed in luminal epithelium, glandular epithelium, and stroma of human and mouse uteri, with dynamic regulation across the menstrual cycle and early pregnancy. EGR2 expression declined in aged and

Identifiers

PMID41323439
PMCPMC12658588

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.