Evidence map›Paper›PMID 41323575›Full record

ArticleMed-X2025

Frontiers in mechanobiology and mechanomedicine.

Priscilla Y Hwang, Panagiotis Mistriotis, Haogang Cai, Longwei Liu, Bo Zhang, Quinton Smith, Jacopo Ferruzzi, Peter Yingxiao Wang, Song Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Med-X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Priscilla Y HwangDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA USA.ORCID 0000-0002-7027-3990
Panagiotis MistriotisDepartment of Chemical Engineering, Auburn University, Auburn, AL USA.
Haogang CaiTech4Health Institute and Department of Radiology, NYU Langone Health, New York, NY USA.
Longwei LiuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA USA.
Bo ZhangDepartment of Bioengineering and Medicine, University of California at Los Angeles, Los Angeles, CA USA.
Quinton SmithDepartment of Chemical and Biomolecular Engineering, University of California at Irvine, Irvine, CA USA.
Jacopo FerruzziDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX USA.
Peter Yingxiao WangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA USA.
Song LiDepartment of Bioengineering and Medicine, University of California at Los Angeles, Los Angeles, CA USA.

Funding

Multimodal wireless electrical stimulation for tissue regenerationR01NS126918 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Song Li, John Rogers · 2022 to 2026
$2.4M
Cell mechanoresponses in physiologically relevant microenvironmentsR35GM147101 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Panagiotis Mistriotis · 2022 to 2026
$2.1M
Mechanopriming for cell engineeringR01NS130677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Song Li · 2023 to 2026
$2.1M
Support for Undergraduate Summer Research ExperienceR35GM147406 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Haogang Cai · 2022 to 2026
$2.0M
Regulation of cell reprogramming by matrix stiffnessR01GM143485 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2021 to 2024
$1.3M
Dissecting mechanisms of collective migrationR35GM155045 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Priscilla Y Hwang · 2024 to 2026
$1.1M
Development of single fluorophore biosensors for multiplex imaging of CAR T SignalingK01EB035649 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Longwei Liu · 2024 to 2026
$455k
NIBIB NIH HHS K01 EB035649NIGMS NIH HHS R01 GM143485NIGMS NIH HHS R35 GM147101NIGMS NIH HHS R35 GM147406NIGMS NIH HHS R35 GM155045NINDS NIH HHS R01 NS126918NINDS NIH HHS R01 NS130677
6 · The paper itself

Abstract

This perspective derives from the presentations and discussions on mechanobiology at the 2025 Cellular and Molecular Bioengineering Conference in San Diego. Mechanobiological processes play critical roles in tissue development, regeneration, and disease progression. Recent advances in engineering, biology, and medicine have enabled the translation of mechanobiology discoveries into clinical practice, giving rise to the emerging field of mechanomedicine. The development and application of engineering technology and tools have provided new insights into how mechanical cues regulate immune cell response, stem cell differentiation, cell migration, and cell metabolism. In this perspective, we highlight exciting discoveries and innovative tools in mechanobiology research, and discuss challenges that must be overcome to truly bridge the gap between mechanobiology and mechanomedicine. Graphical Abstract:

Indexed as

Cell engineeringCell metabolismCell migrationImmunoengineeringMechanomedicineNanopatterning

Identifiers

PMID41323575
PMCPMC12662876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.