ArticleFrontiers in aging neuroscience2025
Excitatory-inhibitory imbalance in temporal lobe epilepsy: a 5T multimodal MRI biomarker for focus localization and drug resistance stratification.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to investigate the diagnostic value of combined glutamate chemical exchange saturation transfer (GluCEST) imaging and γ-aminobutyric acid (GABA)-edited proton magnetic resonance spectroscopy ( Results: GluCEST-derived hippocampal asymmetry [DAIglu_H(epi)] effectively lateralized epileptogenic foci (AUC = 0.86). The DRES patients exhibited elevated DAIglu_H (adjusted Conclusion: Multimodal 5T MRI integrating GluCEST and GABA-MRS provides a clinically feasible tool for lateralizing epileptogenic foci and stratifying drug resistance in TLE. The observed excitatory-inhibitory imbalance dynamics suggest distinct neurometabolic profiles underlying DR and DRES, advancing personalized therapeutic strategies.
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