Evidence map›Paper›PMID 41323658›Full record

SynthesisFrontiers in aging neuroscience2025

Effects of glucocerebrosidase gene variations on the risk of Parkinson's disease dementia: a meta-analysis.

Qiujie Li, Zhumei Bi, Weiming Liang, Shan Yin, Huaicheng Li, Zhongyou Liang, Minyao Wu, Jieru Quan, Cheng Li

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiujie Li *The First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Zhumei Bi *The First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Weiming Liang *The First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Shan YinThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Huaicheng LiThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Zhongyou LiangThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Minyao WuThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Jieru QuanSchool of Economics and Management, Guangxi University of Science and Technology, Liuzhou, Guangxi, China.
Cheng LiDepartment of Geriatrics, Hezhou Guangji Hospital, Hospital, Hezhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This meta-analysis aimed to investigate the effects of glucocerebrosidase gene (GBA) variations on the risk of Parkinson's disease dementia (PDD) and to identify the relationship between GBA variations and PDD. Method: A comprehensive search was performed to retrieve publications from PubMed, Cochrane Library, Embase and Web of Science up to March 19, 2025. The search terms included "glucocerebrosidase," "Parkinson's disease," and "dementia." After rigorous screening, cohort studies were included for meta-analysis. Results: This meta-analysis revealed a significant overall association between the presence of GBA variation and an increased risk of dementia in PD patients (RR = 1.82, 95% CI: 1.52-2.18, Conclusion: GBA variations are significant risk factors for PDD, with varying degrees of risk conferred by different variants. These findings underscore the critical role of GBA in the pathogenesis of PDD and highlight its potential as a key genetic risk factor. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?, Identifier CRD420251109378.

Indexed as

dementiagene variationsglucocerebrosidasemeta-analysisParkinson’s disease

Identifiers

PMID41323658
PMCPMC12660284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.