ArticleCurrent developments in nutrition2025
A Randomized Controlled Trial of a Partially Hydrolyzed Formula on Comfort Measures in Fussy Infants.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05245422 (Parent And Infant Relief), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Parent And Infant Relief (PAIR): Acceptance of a Partially Hydrolyzed Formula
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16 authors.
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Abstract
Background: Parent-reported fussiness and crying are common during early infancy and may be alleviated by switching the formula for infants who are formula fed. Objectives: This study evaluated the nutritive effects of a partially hydrolyzed cow milk protein (PHP) formula with an added prebiotic blend on parent/caregiver-reported fussiness and other measures of comfort in infants with perceived fussiness. Methods: Infants (15-75 d of age) exclusively receiving a commercial intact protein infant formula and rated moderately, very, or extremely fussy were randomized to receive intact cow milk protein formula (control, Results: Of 149 infants randomly assigned, 127 completed study feeding (control, Conclusion: In infants with parent-perceived fussiness, a partially hydrolyzed cow milk protein formula with an added prebiotic blend, INV-PHP, does not decrease fussiness when compared with control formula but does reduce crying and excessive crying.The study was registered at clinicaltrials.gov as NCT05245422.
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