ArticleRSC advances2025
Polymer-lipid hybrid nanoparticles incorporating green coffee extract: enhancing treatment for hepatic steatosis and fibrosis through metabolomic insights.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 30% of adults globally. Its severe form, metabolic dysfunction-associated steatohepatitis (MASH), results in liver damage due to a combination of steatosis and fibrosis. Green coffee extract (GCE) derived from unroasted coffee beans demonstrates therapeutic potential for MASLD/MASH attributed to its rich profile of bioactive compounds. However, challenges remain regarding bioavailability and understanding of mechanisms. In this study, we investigated the bioactive potential of GCE encapsulated in polymer-lipid hybrid nanoparticles (PLNs) as a therapeutic option for MASLD and associated fibrosis. Encapsulation of GCE into PLNs enhanced its physicochemical properties, including reduced particle size (191.5 ± 3.6 nm) and improved polydispersity index (PDI) (0.291), as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM) (145.4 ± 26 nm). The encapsulation efficiency (55%) and release kinetics of GCE-PLNs were optimized for sustained bioavailability over 24 h. Metabolomic and chemoinformatic analyses identified 1942 metabolites, including GCE-derived bioactive compounds with structural similarities to therapeutic agents like mesalamine, idebenone, and cysteamine, highlighting potential antifibrotic and hepatoprotective effects.
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Registered trials
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