Evidence map›Paper›PMID 41323746›Full record

ReviewInternational journal of cardiology. Cardiovascular risk and prevention2025

Phenotype-specific associations of circulating adipokine levels with carotid atherosclerosis: a systematic review and meta-analysis.

Shuo Yang, Hong Shen, Yukun You, Zhenyue Fu, Shuaijie Guo, Yifan Zhang, Qincheng Liu, Ying Yang, Ye Li, Ji Qin and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuo YangDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hong ShenDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yukun YouDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhenyue FuDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shuaijie GuoDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yifan ZhangDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qincheng LiuJiangpu Community Health Service Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying YangShanggang Community Health Service Center, Pudong New Area, Shanghai, China.
Ye LiShanggang Community Health Service Center, Pudong New Area, Shanghai, China.
Ji QinHangtou Hesha Community Health Service Center, Pudong New Area, Shanghai, China.
Ping LiuDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atherosclerosis (AS) is driven by inflammatory and metabolic dysregulation. Carotid atherosclerosis (CA), assessable by ultrasonographic carotid intima-media thickness (cIMT) and plaque, provides a noninvasive window into AS. Adipose tissue-derived adipokines are involved in AS. Aim: We conducted a phenotype-specific systematic review and meta-analysis of observational studies to quantify associations between circulating adipokines and CA. Methods: Following a preregistered protocol, PubMed, Embase, and Web of Science were searched. Adults with ultrasound-defined CA (increased cIMT and/or carotid plaque) and controls were included. Mean and standard deviation (SD) of circulating adipokines were extracted and converted to standardized mean difference (SMD) for pooled analysis. Results: Nineteen studies (n = 5860; Asia/Europe/Americas; 8 cross-sectional, 8 case-control, 3 cohort) were included for quantitative analysis. In the increased cIMT phenotype, adiponectin was lower in CA [SMD = -0.72 (-1.00, -0.44), Conclusions: This study indicated that circulating adipokine levels can serve as phenotype-specific biomarkers in CA.

Indexed as

AdipokinesAdiponectinCarotid atherosclerosisLeptinMeta-analysisOmentinSystematic review

Identifiers

PMID41323746
PMCPMC12662000

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.