Evidence map›Paper›PMID 41323991›Full record

ArticleFrontiers in nutrition2025

Immune imbalance mediates the relationship between plasma vitamin D concentration and preeclampsia in Chinese pregnant women: a case-control study.

Huanan Chen, Yacong Bo, Yuan Cao, Jinyan Liu, Jiaqi Nie, Dandan Duan, Weifeng Dou, Xianlan Zhao, Wenjun Fu, Yi Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huanan Chen *Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yacong Bo *Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yuan CaoThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jinyan LiuBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jiaqi NieDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Dandan DuanDepartment of Clinical Nutrition, Luoyang New Area People's Hospital, Luoyang, China.
Weifeng DouDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Xianlan ZhaoDepartment of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenjun FuDepartment of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yi ZhangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yanhua LiuDepartment of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin D insufficiency is associated with an increased risk of preeclampsia. However, the role of T helper cell type 1 (Th1)/Th2 and Th17/regulatory T cell (Treg) balance in this association is unclear. Methods: We conducted a case-control study to explore the mediating effects of immune balance on the relationship between the plasma vitamin D concentration and preeclampsia. This study included 373 pregnant women recruited between March 2016 and February 2019 (192 cases and 181 controls). The cytokines as well as various T cell subsets were analyzed using ELISA and flow cytometry, respectively. Spearman's correlation was used to investigate the association between vitamin D and cytokines as well as T cell subsets and mediating analysis was performed to identify the modifying effects of immune balance on this association. Results: The Th1/Th2 and Th17/Treg ratios were negatively associated with the plasma concentration of 25-hydroxyvitamin D Conclusion: Our results provided preliminary evidence for a potential mediating role of the Th1/Th2 and Th17/Treg balance in the association between plasma 25(OH)D

Indexed as

Chineseimmune imbalancemediation effectpreeclampsiavitamin D

Identifiers

PMID41323991
PMCPMC12661851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.