ArticleJournal of musculoskeletal & neuronal interactions2025
Hindlimb Suspension and Subsequent Weight-Loading on Femoral Morphology, Knee Joint Alignment, and Patellar Tracking in Growing Rats.
Article in Journal of musculoskeletal & neuronal interactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Age-Dependent Susceptibility to Mechanical Unloading-Induced Femoral Morphological Changes and Patellar Instability in a Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Anatomical Risk Factors for Lower Extremity Musculoskeletal Disorders and Proposed Prevention Strategies.Physical therapy research · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesReduced weight-loading on the lower extremities during growth induces abnormal bone morphology and malalignment, but the effects of reloading on these abnormalities remain unknown. We aimed to determine the specific timeframes in which hindlimb suspension (HS) during growth induces abnormal femoral morphologies and knee malalignments present at skeletal maturity in rats.
methodsFour-week-old female rats were subjected to HS for one, two, or four weeks using the tail suspension method, followed by reloading. Age-matched rats were used as controls. At 12 weeks of age, femoral morphology and knee joint alignment were assessed using X-ray computed tomography.
resultsFemoral anteversion angle, medial/lateral condylar height ratio (MC/LC), and patellar tilt angle were significantly larger, while trochlear angle, lateral condylar height (LC), and lateral trochlear inclination (LTI) were smaller in the groups that underwent HS for two or four weeks prior to reloading, compared with the control group. There were significant correlations between LTI and LC (r = 0.57), MC/LC (r = -0.42), and patellar tilt angle (r = -0.49). In the 4-week HS group, lateral patellar dislocation was observed in 3 of 8 animals.
conclusionInsufficient weight-loading more than two weeks during growth may induce knee joint instability even after reloading.
Indexed as
Identifiers
41324218PMC12684259What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.