ArticleJournal of musculoskeletal & neuronal interactions2025
Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.
Article in Journal of musculoskeletal & neuronal interactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOsteoporosis (OP) is a major public health concern characterized by increased bone fragility. This study aimed to investigate the causal relationship between circulating metabolites, particularly lipid-related metabolites, and OP using Mendelian Randomization (MR).
methodsA bidirectional two-sample MR approach was applied using summary statistics from large-scale Genome-Wide Association Studies (GWAS) comprising 484,598 individuals of European ancestry. Genetic variants associated with circulating metabolites were selected as instrumental variables. Causal effects were estimated using inverse variance weighting (IVW), weighted median, and MR-Egger methods. Sensitivity analyses were conducted to assess heterogeneity and pleiotropy.
resultsMR analyses indicated a potential causal relationship between higher levels of monounsaturated fatty acids (MUFA) and a reduced risk of OP (OR = 0.997; 95% CI: 0.994-0.999; P = 0.013). Conversely, increased total lipids in lipoprotein particles were associated with a higher OP risk (OR = 1.002; 95% CI: 1.000-1.004; P = 0.031). In addition, OP was inversely associated with total lipids (OR = 0.269; 95% CI: 0.095-0.759; P = 0.013) and triglycerides (OR = 0.259; 95% CI: 0.090-0.745; P = 0.012) in chylomicrons and extremely large very-low-density lipoproteins. No evidence of pleiotropy or heterogeneity was detected.
conclusionThis study provides genetic evidence for causal links between lipid metabolism and OP, suggesting that circulating lipid metabolites may serve as potential biomarkers for risk stratification and prevention.
Indexed as
Identifiers
41324219PMC12684268What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.