Evidence map›Paper›PMID 41324562›Full record

ArticleBJS open2025

Abnormal gastric electrophysiology following laparoscopic sleeve gastrectomy and associations with symptoms and quality of life.

Tim Hsu-Han Wang, Chris Varghese, Sam Robertson, Grant Beban, Nicholas Evennett, Daphne Foong, Vincent Ho, Christopher N Andrews, Stefan Calder, Armen Gharibans and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tim Hsu-Han WangDepartment of Surgery, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-6200-2384
Chris VargheseDepartment of Surgery, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-7369-8639
Sam RobertsonDepartment of Surgery, The University of Auckland, Auckland, New Zealand.
Grant BebanDepartment of Surgery, Auckland City Hospital, Auckland, New Zealand.
Nicholas EvennettDepartment of Surgery, Auckland City Hospital, Auckland, New Zealand.
Daphne FoongSchool of Medicine, Western Sydney University, Sydney, New South Wales, Australia.
Vincent HoSchool of Medicine, Western Sydney University, Sydney, New South Wales, Australia.
Christopher N AndrewsDivision of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.
Stefan CalderDepartment of Surgery, The University of Auckland, Auckland, New Zealand.
Armen GharibansDepartment of Surgery, The University of Auckland, Auckland, New Zealand.
Gabriel SchambergDepartment of Surgery, The University of Auckland, Auckland, New Zealand.
Greg O'GradyDepartment of Surgery, The University of Auckland, Auckland, New Zealand.

Funding

Auckland Medical Research FoundationNew Zealand Health Research CouncilThe Royal Australasian College of Surgeons R56 126935
6 · The paper itself

Abstract

backgroundSleeve gastrectomy is an effective bariatric procedure but may lead to persistent symptoms without obvious mechanical cause. The normal gastric pacemaker region, which lies on the greater curvature of the corpus, is resected in sleeve gastrectomy, but the electrophysiological consequences are not adequately defined. This study assessed these impacts and associations with symptoms and quality of life (QoL) using non-invasive gastric mapping.

methodsPatients with previous sleeve gastrectomy underwent body surface gastric mapping (Gastric Alimetry), comprising 30-minute fasting baseline and 4-hour post-prandial recordings. Analysis encompassed principal gastric frequency (PGF), body mass index-adjusted amplitude, and the Gastric Alimetry Rhythm Index (GA-RI), with comparison to reference intervals and matched controls. Symptoms were evaluated using a validated app and questionnaires.

resultsThe study recruited 38 patients (median 36 months after surgery; range 6-119 months) and 38 controls. Of the 38 patients, 35 had at least one abnormal parameter compared with controls, typically reduced frequencies (mean(standard deviation) 2.30(0.34) versus 3.08(0.21) c.p.m., respectively; P < 0.001) and amplitudes (14.8(6.9) versus 31.5(18.0) µV, respectively; P < 0.001). Patients exhibited higher symptoms and lower QoL than the controls (Patient Assessment of Upper Gastrointestinal Disorders (PAGI) Symptoms Questionnaire scores 20 versus 7, respectively (P < 0.001); PAGI-QOL 27 versus 136, respectively (P < 0.001)). Gastric amplitude (R = 0.71, P < 0.001) and the GA-RI (R = 0.60, P = 0.02) were positively correlated with bloating, whereas amplitude was negatively correlated with heartburn (R = -0.46, P = 0.03). Lower gastric amplitudes were also correlated with greater weight loss (R = -0.45; P = 0.014).

conclusionSleeve gastrectomy modifies gastric electrophysiology due to pacemaker resection, with variable remodelling. Substantial reductions in gastric frequency and amplitude occur routinely after surgery, with specific associations between post-procedural gastric amplitude and symptoms of heartburn, bloating, and weight loss identified.

Indexed as

GastrectomyLaparoscopyObesity, MorbidPostoperative ComplicationsQuality of LifeStomachAdultBody Mass IndexCase-Control StudiesFemaleHumansMaleMiddle AgedSurveys and Questionnairesbody surface gastric mappingGastric Alimetrygastric myoelectrical activityhigh-resolution electrogastrographyslow waves

Identifiers

PMID41324562
PMCPMC12667261

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.