Observational studySurgery today2026
Periodontitis as a potential predisposing factor for gallstone cholecystitis: exploring the role of chronic systemic inflammation.
Observational study in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
purposePeriodontitis is a chronic oral disease that contributes to low-grade systemic inflammation and may predispose to extraoral complications. We conducted this study to analyze its association with gallstone-related cholecystitis.
methodsThe subjects of this prospective observational study were 160 adults with acute calculous cholecystitis or symptomatic cholelithiasis. The patients were grouped according to their periodontal status as having “normal/mild” or “moderate/severe” peridontitis. We calculated the inflammatory indices: the lymphocyte-to-C-reactive protein ratio (LCR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (d-NLR), and platelet-to-lymphocyte ratio (PLR); and analyzed the associations between periodontal status, inflammatory markers, and gallbladder pathology, using univariate and multivariate models.
resultsModerate/severe periodontitis was found significantly more frequently in patients with cholecystitis than in those with uncomplicated gallstones (80% vs. 22.5%, p < 0.001). Patients with cholecystitis had lower LCR and higher NLR, d-NLR, and PLR values (all p < 0.05). Multivariate analysis identified periodontitis (HR = 1.797) and all inflammatory markers as independent predictors of cholecystitis. Severe periodontitis was especially prevalent in patients with active acute cholecystitis.
conclusionPeriodontitis is significantly associated with acute cholecystitis, potentially through systemic inflammatory mechanisms. Thus, periodontal evaluation may be important in the management and prevention of biliary tract complications.
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