Evidence map›Paper›PMID 41324749›Full record

ArticleEuropean journal of nutrition2025

Intake of one-carbon metabolism nutrients and risk of rheumatoid arthritis: a prospective UK biobank cohort study.

Shiyong Zhang, Bin Xia, Yunze Kang, Yongsheng Wang, Zixin Liang, Qiangsheng He, Xudong Wang, Peng Xie, Ningning Mi, Jinqiu Yuan and 2 more

Abstract read
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In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shiyong ZhangDepartment of Orthopedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China.
Bin XiaDepartment of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China.
Yunze KangDepartment of Joint Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
Yongsheng WangHealth Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
Zixin LiangDepartment of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China.
Qiangsheng HeDepartment of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China.
Xudong WangDepartment of Orthopedics, Sun Yat-Sen Memorial Hospital, Guangzhou, China.
Peng XieCenter for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Ningning MiCenter for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Jinqiu YuanDepartment of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China. yuanjq5@mail.sysu.edu.cn.
Fuxin WeiDepartment of Orthopedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong, China. weifuxin@mail.sysu.edu.cn.
Ziji ZhangDepartment of Joint Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. zhangziji@mail.sysu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110126Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515140147National Natural Science Foundation of China 82272534Natural Science Foundation of Guangdong Province 2022A1515012279
6 · The paper itself

Abstract

objectivesOne-carbon metabolism (OCM) nutrients are essential for methylation processes and may be involved in the pathogenesis of rheumatoid arthritis (RA), but prospective evidence remains limited. This study aimed to investigate the association between dietary OCM nutrients and RA risk, and their interactions with genetic and lifestyle factors.

methodsA total of 189,440 participants from the UK Biobank were included. Dietary intake was assessed using repeated 24-hour recalls. Nutrient levels were estimated based on McCance and Widdowson's The Composition of Foods and the USDA Food and Nutrient Database for Dietary Studies. Cox proportional hazards models were used to evaluate the independent and joint associations of OCM nutrients, genetic risk, and RA risk. Nonlinear associations were examined using restricted cubic spline.

resultsDuring a median follow-up of 13.43 years, 1,751 RA cases were identified. Participants in the highest quartile of OCM nutrient intake had a significantly lower risk of RA compared to those in the lowest quartile. The hazard ratios (95% CI) for methionine, folate, vitamin B6, and vitamin B12 were 0.84 (0.74-0.97), 0.88 (0.76-1.00), 0.88 (0.78-0.98), and 0.84 (0.73-0.96), respectively. High OCM intake combined with low genetic risk was associated with a > 40% lower risk of RA. Additionally, significant interactions were observed between OCM nutrient intake and both smoking and alcohol consumption.

conclusionHigher intake of OCM nutrients was associated with a reduced risk of RA and showed a joint effect with genetic risk. Individuals with certain lifestyle factors may benefit more from dietary OCM nutrient intake.

Indexed as

Arthritis, RheumatoidCarbonDietNutrientsAdultAgedBiological Specimen BanksCohort StudiesFemaleFolic AcidHumansMaleMethionineMiddle AgedProportional Hazards ModelsProspective StudiesCarbonFolic AcidMethionineNutrientsVitamin B 12Vitamin B 6MethionineOne-carbon metabolismProspective cohort studyRheumatoid arthritisUK biobank

Identifiers

PMID41324749

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.