Evidence map›Paper›PMID 41324759›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

G Osthoff, S Mason, F Deacon

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeted metabolomics of organic and amino acids in giraffe milk during mid- to late-lactation.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

G OsthoffDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa. osthoffg@ufs.ac.za.ORCID http://orcid.org/0000-0002-1008-4602
S MasonBiomedical and Molecular Metabolism Research (BioMMet), Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.ORCID http://orcid.org/0000-0002-2945-5768
F DeaconDepartment of Animal, Wildlife and Grassland Sciences, University of the Free State, Bloemfontein, 9300, South Africa.ORCID http://orcid.org/0000-0001-6500-4625

Funding

National Research Foundation 85939Universiteit van die Vrystaat 27241
6 · The paper itself

Abstract

backgroundDynamic changes in milk components during the end stages of lactation (involution) occur in all mammals. The time required to reach complete cessation may differ among taxa and species. The involution of cows, sheep, and goats (Bovidae) has been studied, but information on Giraffes is lacking.

objectivesCharacterize the milk metabolome of giraffes at involution.

methodsMilk was obtained from five giraffes. Notably, all giraffes followed the same diet, a factor known to influence milk composition in domesticated mammals. Milk serum was prepared by filtration of the milk samples. A

resultsThe changes in metabolites were characterised at 9.4, 12, and 15.1 months of lactation. Protein-type amino acids increased, while organic acids and lipid metabolites, as well as carbohydrates and their derivatives, decreased. This indicated that the synthesis of amino acids and proteins was upregulated, while that of lipids and carbohydrates was downregulated. Energy-producing amino acids and citric acid cycle intermediates decreased, suggesting reduced availability of energy metabolites.

conclusionsInvolution, along with the associated changes in the giraffe's milk metabolome may commence at 12 months of lactation but is complete by 15 months.

Indexed as

LactationMetabolomicsMilkAmino AcidsAnimalsFemaleGoatsMagnetic Resonance SpectroscopyMetabolomeProton Magnetic Resonance SpectroscopyAmino Acids1H-NMRDry-outGiraffeInvolutionLactationMetaboliteMilkRuminant

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.