SynthesisClinical and experimental nephrology2026
Dialysis modality and cognitive outcomes in chronic kidney disease: a systematic review and meta-analysis.
Synthesis in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan.The journal of prevention of Alzheimer's disease · 2026Article
- Neuro-Renal Crosstalk Across the Chronic Kidney Disease Spectrum: Stage-Dependent Molecular Mechanisms of Cognitive Impairment-An Integrative Review.International journal of molecular sciences · 2026Review
- Comments on "Dialysis modality and cognitive outcomes in chronic kidney disease: a systematic review and meta-analysis".Clinical and experimental nephrology · 2026Article
- Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is a prevalent comorbidity in patients with chronic kidney disease (CKD). While hemodialysis (HD) and peritoneal dialysis (PD) are established renal replacement therapies, their relative effects on cognitive outcomes remain unclear. This meta-analysis compared cognitive outcomes between HD and PD in CKD patients.
methodsThe protocol was prospectively registered on PROSPERO (CRD42024602533). PubMed, CENTRAL, Embase, Medline, Web of Science, PsychInfo, and CINAHL were searched from January 2000 to January 2025. Eligible studies included cohort studies of adult patients undergoing HD versus PD. Primary outcomes were cognitive function and dementia incidence. A random-effects meta-analysis model was used. Risk of bias was assessed using ROBINS-I, and evidence quality was evaluated using GRADE. Methodological rigor was benchmarked against previous reviews using AMSTAR 2.0.
resultsThe search identified 1489 studies, of which 26, involving 326,216 patients, were included. There was a statistically significant difference in overall cognitive function between HD and PD (SMD: -0.46; 95% CI: -0.62 to -0.29; p < 0.00001; I
conclusionsQuantitative analyses revealed significant evidence, and qualitative trends suggest PD may be associated with better cognitive outcomes in select domains. These findings underscore the need to individualize dialysis modality decisions based on cognitive risk profiles and conduct further standardized research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.