ArticleThe AAPS journal2025
Preclinical Development of GT-14, a Novel Inhibitor of Gα
Mahua Sarkar, Ting Du, Yuan Chen, Yen V Maroney Lawrence, Jing Ma, Shafiq A Khan, Adegboyega K Oyelere, Dong Liang, Song Gao, Huan Xie
Abstract read
In one paragraphArticle in The AAPS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Mahua SarkarDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0001-6899-0088 Ting DuDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0002-7705-6913 Yuan ChenDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0001-8676-0913 Yen V Maroney LawrenceDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0009-0003-1720-7358 Jing MaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0002-9233-0247 Shafiq A KhanCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Dr., Atlanta, Georgia, 30314, U.S.A.ORCID 0000-0002-1010-313X Adegboyega K OyelereSchool of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia, 30318, U.S.A.ORCID 0000-0002-2248-9551 Dong LiangDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0001-6632-8066 Song GaoDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.ORCID 0000-0003-2361-3494 Huan XieDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, U.S.A.. huan.xie@tsu.edu.ORCID 0000-0002-0591-5619 Funding
Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination TherapyU54MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI Dong Liang, Huan Xie · 2020 to 2026
$22.0MNIMHD NIH HHS U54 MD007605
6 · The paper itselfAbstract
GT-14, identified as [(E)-4-((1-(1-methyl-1H-indol-2-yl) ethylidene)amino)phenol], is a novel inhibitor targeting the Gα
Indexed as
IndolesAnimalsCaco-2 CellsDrug DevelopmentDrug Evaluation, PreclinicalHumansHydrogen-Ion ConcentrationMaleMicrosomes, LiverRatsRats, Sprague-DawleySolubilityTissue DistributionIndolesgαi2 proteinmetabolismphysico-chemical propertiespreclinical developmenttissue distribution
Identifiers
PMID41324835
PMCPMC13050480
What Socratic holds
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