Evidence map›Paper›PMID 41324868›Full record

ArticleHormones (Athens, Greece)2026

The impact of triglyceride-glucose-related obesity indices and sleep patterns on accelerated aging: evidence from NHANES 2005-2018.

Xiaoxuan Chu, Lu Zhang, Hao Zhu, Shuaijie Gao, Zhenwei Wang, Shu Wang, Na Liang, Jie Lu

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Article in Hormones (Athens, Greece), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoxuan ChuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Lu ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Hao ZhuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Shuaijie GaoDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Zhenwei WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Shu WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Na LiangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Jie LuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China. hanyaa800@zzu.edu.cn.ORCID http://orcid.org/0000-0003-1503-3801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to explore the association between triglyceride-glucose (TyG)- related obesity indices, sleep patterns, and phenotypic age.

methodsThis study examined three TyG-related obesity indices, namely, TyG-WC (waist circumference), TyG-WHtR (waist-to-height ratio), and TyG-BMI (body mass index). Sleep patterns are categorized as healthy or poor. Weighted linear regression was employed to examine the relationship between TyG-related obesity indices, sleep patterns, and phenotypic age acceleration (PhenoAgeAccel). The XGBoost model was used to assess the relative importance of variables affecting accelerated aging. Nonlinear associations were explored using generalized additive models (GAM) or weighted restricted cubic splines (RCS). Stratified analyses by sleep patterns assessed their potential modification of the relationship between TyG-related obesity indices and PhenoAgeAccel.

resultsAll TyG-related obesity indices were associated with PhenoAgeAccel (all P<0.05). GAM revealed an inverse L-shaped relationship between TyG-related obesity indices and accelerated aging. XGBoost modeling indicated that TyG-WC contributed more to accelerated aging than TyG-BMI and TyG-WHtR. Weighted RCS analysis showed a U-shaped relationship between sleep duration and accelerated aging (P for nonlinear <0.001). We also observed that TyG-related obesity indices showed stronger effects on accelerated aging in the poor sleep pattern group (β range: 0.03- 1.55) and that the effects decreased in the healthy sleep pattern group (β range: 0.02 - 1.30).

conclusionHigher TyG-related obesity indices were linked to increased risk of accelerated aging. Sleep patterns may modify the relationship between TyG-related obesity indices and accelerated aging.

Indexed as

AgingAging, PrematureBlood GlucoseObesitySleepTriglyceridesAdultAgedBody Mass IndexFemaleHumansMaleMiddle AgedNutrition SurveysWaist CircumferenceBlood GlucoseTriglyceridesInfluential factorInsulin resistancePhenotypic ageXGBoost model

Identifiers

PMID41324868

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.