ArticleClinical journal of the American Society of Nephrology : CJASN2026
Proteomic Markers of Dietary Patterns, CKD Progression, and Mortality in the CRIC Study.
Valerie K Sullivan, Jingsha Chen, Lawrence J Appel, Sarah Schrauben, Ana C Ricardo, Panduranga Rao, Mirela Dobre, Nishigandha Pradhan, Jing Chen, Jiang He and 4 more
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In one paragraphArticle in Clinical journal of the American Society of Nephrology : CJASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Valerie K SullivanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-2321-0188 Jingsha ChenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Lawrence J AppelDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-0673-6823 Sarah SchraubenDepartments of Medicine and Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-2557-5161 Ana C RicardoDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, Illinois.ORCID 0000-0001-8670-3644 Panduranga RaoDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-4699-5395 Mirela DobreDivision of Nephrology and Hypertension, University Hospital Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0002-9059-9998 Nishigandha PradhanDivision of Nephrology and Hypertension, University Hospital Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.
Jing ChenDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-9035-9126 Jiang HeDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-8286-9652 Paul L KimmelDepartment of Medicine, George Washington University, Washington, DC.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-5442-8745 CRIC Study Investigators*
Funding
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2MScientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MMichigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MJohns Hopkins Institute for Clinical and Translational ResearchUM1TR004926 · NCATS · JOHNS HOPKINS UNIVERSITY · PI STEPHEN N. DAVIS, Daniel Ernest Ford · 2024 to 2026
$28.5MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MContinuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5MZonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI WATSON, DOUGLAS · 2002 to 2009
$20.2MStudy of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5MLimited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3MProspective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0MJohns Hopkins University UL1 TR-000424Kaiser Permanente NIH/NCRR UCSF-CTSI UL1 RR-024131Michigan Institute for Clinical and Health Research UL1TR000433NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1TR000003, UL1TR000439, 1UM1TR004926NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UM1 TR004926NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NHLBI NIH HHS R01 HL153178NIDDK NIH HHS R01 DK119199NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U01 DK108809NIDDK NIH HHS U01DK108809, U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902 and U24DK060990NIDDK NIH HHS U24 DK060990NIDDK NIH HHS U54 DK137331NIGMS NIH HHS P20 GM109036School of Medicine, University of New Mexico NM R01DK119199University of Illinois at Chicago CTSA UL1RR029879University of Maryland GCRC M01 RR-16500
6 · The paper itselfAbstract
key pointsUsing untargeted proteomics, we identified 199 plasma protein markers of four healthy dietary patterns in adults with CKD. Twenty-one diet-related proteins were associated with CKD progression and 30 proteins were associated with all-cause mortality. These proteins may represent biologic mechanisms through which diet modifies disease course in CKD.
backgroundHealthy dietary patterns reduce the risk of CKD progression and mortality in people with CKD. Identifying protein biomarkers of diet, and their associations with these outcomes, can elucidate biologic mechanisms through which diet improves prognosis.
methodsUsing data from the Chronic Renal Insufficiency Cohort study of adults with CKD ( n =2217, mean age 59 years), we examined cross-sectional associations between 4954 plasma proteins and four dietary patterns: Healthy Eating Index-2020, Alternative Healthy Eating Index-2010, Dietary Approaches to Stop Hypertension, and alternate Mediterranean diet. Relative values of proteins were determined using an aptamer-based assay. Dietary intake was assessed using a food frequency questionnaire. We used multivariable linear regression to identify proteins associated with diet, and Cox proportional hazards regression to assess longitudinal associations between diet-related proteins, CKD progression, and mortality. Elastic net regression was used to select subsets of proteins that are associated with these outcomes.
resultsAt a false discovery rate-adjusted P < 0.05, 199 proteins were associated with ≥1 dietary pattern and 18 were associated with all patterns. Over 7 years of median follow-up, 824 CKD progression events occurred. Twenty-one proteins were associated with CKD progression at P < 2.5×10 -4 (=0.05/199), of which eight were selected in elastic net regression: follistatin-related protein 3, glutaredoxin-1, asialoglycoprotein receptor 1, extracellular superoxide dismutase [Cu-Zn], zinc- α -2-glycoprotein, IL-18 receptor 1, ecto-ADP-ribosyltransferase 3, and ephrin type-A receptor 1. All were inversely associated with healthy dietary patterns and associated with higher risk of CKD progression. Thirty proteins were associated with all-cause mortality, of which 14 were selected by elastic net regression.
conclusionsLarge-scale proteomics analyses identified potential protein biomarkers of healthy dietary patterns that were associated with CKD progression and mortality in adults with CKD. Their functions, including regulating blood lipids, insulin sensitivity, vascular homeostasis, inflammation, and oxidative stress, may represent mechanisms through which diet improves disease course.
Indexed as
Blood ProteinsDiet, HealthyProteomicsRenal Insufficiency, ChronicAgedBiomarkersCross-Sectional StudiesDietary Approaches To Stop HypertensionDiet, MediterraneanDisease ProgressionFemaleHumansMaleMiddle AgedBiomarkersBlood Proteinsnutritionprogression of renal failureproteomics
Identifiers
PMID41325160
PMCPMC13024324
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