Observational studyBlood transfusion = Trasfusione del sangue
Improving blood safety: NAT-based detection of Plasmodium spp. in blood donors in endemic areas of Brazil.
Observational study in Blood transfusion = Trasfusione del sangue. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Landscape of Malaria in a Five-Decade Institution in the State of Amazonas: Historical Trends, Scientific Contributions, and Research Priorities.Revista da Sociedade Brasileira de Medicina Tropical · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransfusion-transmitted malaria remains a significant challenge in endemic areas and is a leading cause of blood donation deferral. Rigorous clinical and molecular screening is essential to ensure the safety of blood components. The presence of low-density Plasmodium spp. parasitemia in asymptomatic individuals can compromise transfusion safety and perpetuate disease transmission. This study aimed to describe malaria positivity detected by the NAT PLUS HIV/HBV/HCV/Malaria kit (Bio-Manguinhos), as well as to characterize the epidemiological profile of blood donors and the main deferral causes at a reference blood center in the Brazilian Amazon. MATERIALS AND
methodsThis was a retrospective observational study using secondary data from the HemoSys database, which included sociodemographic variables, clinical screening, and self-reported malaria history from blood donors. Cases of clinical malaria were investigated among NAT PLUS-positive donors within six months before and after the reactive donation.
resultsA total of 67,114 blood donors tested using the NAT PLUS assay were included. The median age was 35 years (IQR 25-43), with a predominance of male donors (65.1%). Most self-identified as mixed race (80.5%) and had completed high school (53.3%). Malaria-related factors accounted for 2.6% of deferrals (No.=27,434). Malaria positivity detected by NAT PLUS assay was 0.01% (8/67,114), with all reactive donors being asymptomatic at screening. Most positive cases (6/8) occurred during the low-transmission period (rainy season). One donor (12.5%) developed symptomatic malaria (P. falciparum), confirmed by thick blood smear and notified in the SIVEP-Malaria system shortly after donation. DISCUSSION: Individuals testing positive for Plasmodium spp. by NAT PLUS assay may progress to clinical malaria post-donation, posing risks to both donor health and transfusion safety. The frequent absence of information on malaria exposure during clinical screening highlights the need for standardized protocols and molecular testing to improve early identification of at-risk donors in endemic regions.
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Registered trials
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