SynthesisAtherosclerosis2026
Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Atherosclerosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
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1citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
1 citing paper in PubMed.
- Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026Review
Corrections and comments
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Authors and funding
151 authors.
Raymond NoordamDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Health Campus the Hague/Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.noordam@lumc.nl.
Wenyi WangDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Michael R BrownDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Qin HuiRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA.
Aldi T KrajaUniversity of Mississippi Medical Center, Jackson, MS, USA.
John L MorrisonDivison of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Jeffrey R O'ConnelDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Songmi LeeBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Karen SchwanderDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Traci M BartzCardiovascular Health Research Unit, Department of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Lisa de Las FuentesCenter for Biostatistics and Data Science, Institute for Informatics, Data Science and Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Mary F FeitosaCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xu HanfeiDepartment of Biostatistics, Boston University, Boston, MA, USA.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Zhijie HuangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Mart KalsEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Christophe LefevreDepartment of Bioinformatics, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Massimo ManginoDepartment of Twin Research, King's College London, London, UK.
Yuri MilaneschiGGZ inGeest, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, the Netherlands.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Natasha L PachecoNational Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Varun RaoDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Quan SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Dina VojinovicDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Yujie WangDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany.
Qian YangMRC Integrative Epidemiology Unit at then University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wanying ZhuDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Md Abu Yusuf AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Hugues AschardInstitut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, 2115, USA.
Pramod AnuguJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Themistocles L AssimesDivision of Cardiology, Department of Medicine, Palo Alto VA Healthcare System, Palo Alta, CA, USA; Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA, USA.
John AttiaSchool of Medicine and Public Health, University of Newcastle, New Lambton Heights, Australia.
Laura D BakerDepartment of Internal Medicine (Geriatrics & Gerontology), Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Christie BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Lydia BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Eric BoerwinkleDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Brain CadeDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Hung-Hsin ChenDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Yii-Der Ida ChenDepartment of Biostatistics, Boston University, Boston, MA, USA.
Zekai ChenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Kelly ChoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Ileana De Anda-DuranDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Latchezar DimitrovDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anh DoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA.
Todd EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Tariq FaquihDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Aroon HingoraniFaculty of Population Health, Institute of Cardiovascular Science, University College London, London, WC1E 6BT, UK.
Susan P Fisher-HochSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.
J Michael GazianoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Sina A GharibPulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Ayush GiriDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
C Charles GuCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
James HixsonDepartment of Epidemiology, UTHealth School of Public Health, Houston TX, USA.
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Michelle M HoodDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Serena C HoughtonMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 2142, USA.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Henry J LinThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Gregorio V LinchangcoRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA.
Annemarie I LuikDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jintao MaNutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, 2111, USA.
James B MeigsPrograms in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, USA.
Joseph B McCormickSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.
Cristina MenniDepartment of Twin Research, King's College London, London, UK.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA.
Lauren E PettyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hannah G PolikowskyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Renata L RihaDepartment of Sleep Medicine, The University of Edinburgh, Edinburgh, UK.
Thomas C RussAlzheimer Scotland, Dementia Research Centre, The University of Edinburgh, Edinburgh, UK; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconness Medical Center, Boston, MA, USA.
Botong ShenNational Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Jingxian TangDepartment of Biostatistics, Boston University, Boston, MA, USA.
Kent D TaylorDivision of Genomic Outcomes, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Rima TriatinDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Biomedical Sciences, Universitas Padjadjaran, Bandung, Indonesia.
Michael Y TsaiLaboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Henry VölzkeDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Kenneth E WestermanPrograms in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.
Rui XiaBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Ruiyuan ZhangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Alan B ZondermanNational Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Jennifer E BelowDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Simon R CoxLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Michelle EvansNational Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Myriam FornageDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Ervin R FoxDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sioban D HarlowDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Elizabeth HollidaySchool of Medicine and Public Health, University of Newcastle, New Lambton Heights, Australia.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Tanika KellyDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Deborah A LawlorMRC Integrative Epidemiology Unit at then University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Changwei LiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ching-Ti LiuDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Alisa K ManningMassachusetts General Hospital, Clinical and Translational Epidemiology Unit, Department of Medicine, Boston, MA, 02114, USA; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Alanna C MorrisonDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Matthias NauckDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Kari E NorthDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Brenda Wjh PenninxGGZ inGeest, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, the Netherlands.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tim D SpectorGGZ inGeest, Amsterdam, the Netherlands.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Lifelines Cohort StudyRoden, the Netherlands.
Million Veteran Program
Cashell E JaquishDivision of Cardiovascular Science, Epidemiology Branch, NHLBI, NIH, Bethesda, MD, 20817, USA.
Peter Wf WilsonRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Patricia B MunroeWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Paul S de VriesDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
W James GaudermanDivison of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Yan V SunRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA.
Han ChenDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Clint L MillerCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Funding
Research Education CoreP30AG024824 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2004 to 2025
$4.4MStatistical Methods for Integrative Genomics in CancerP01CA196569 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$2.5MDissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseasesR01HL153814 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$403kIntramural NIH HHS Z01 HG200362NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R01 HL156991NHLBI NIH HHS R21 HL165324NIA NIH HHS P30 AG024824
Abstract
BACKGROUND AND
aimsDeviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.
methodsWe collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) total sleep time were defined by the extreme 20 % of the age- and sex-standardized values within each cohort. Based on cohort-level summary statistics data, we performed meta-analyses for one-degree of freedom tests of interaction and two-degree of freedom joint tests of the SNP-main and -interaction effect on lipid levels.
resultsThe one-degree of freedom variant-sleep interaction test identified 10 novel loci (P
conclusionsCollectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, these findings may contribute developing novel interventions for treating dyslipidemia in people with sleep disturbances.
Indexed as
DyslipidemiasGenetic LociLipidsSleepSleep Wake DisordersAdultAgedBiomarkersCholesterol, HDLCholesterol, LDLFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedBiomarkersCholesterol, HDLCholesterol, LDLLipidsTriglycerides
Identifiers
What Socratic holds
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